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Unlike normal bone tissue, OI type III cortical bone exhibited more isotropic material properties. Young's modulus and hardness values measured in the longitudinal direction did not show significant differences from the transverse measurements. No differences were observed in modulus or hardness in an analysis of the cortical and trabecular samples. The deformation patterns of the OI type III bone during nanoindentation were found to be similar to those of normal adult bone in an analysis of the ratio of modulus to hardness. No correlation was found between nanoindentation measurement and age in an analysis of regression. \u00a9 2006 Wiley Periodicals, Inc. 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