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The tissue\u2010regenerating effect of RGTA OTR4120 was evaluated after 1\u20136 days and after 10 months in a rat skin burn model. This effect was also examined <jats:italic>in vitro<\/jats:italic> using fibroblasts isolated from control and 6\u2010day\u2010old burned skins. We measured production of dermal collagen I, III, and V and activities of metalloproteinases 2 and 9 (MMP\u20102 and MMP\u20109). Ratio of collagen III over collagen I production increased 6 days after the burn, because of a decrease in collagen I production. After 10 months, ratio of collagen III over collagen I in burn sites was still increased compared with control skin, because of an increase in collagen III production. Both abnormalities were corrected by OTR4120. OTR4120 increased pro\u2010 and active MMP\u20102 and MMP\u20109, compared with healthy and burned controls and therefore accelerated remodeling. Similar data were obtained with cultured fibroblasts from healthy and burned skins. OTR4120 enhanced healing in short\u2010 and long\u2010term after burns, reducing the formation of fibrotic tissue, and then represents a potential agent to improve burned skin healing. \u00a9 2006 Wiley Periodicals, Inc. 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