{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:42:26Z","timestamp":1761154946063},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T00:00:00Z","timestamp":1158710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Excessive polyethylene wear particles from joint replacements may lead to periprosthetic osteolysis and loosening. Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) decrease fracture healing and bone ingrowth. We hypothesized that continuous local infusion of OP\u20101 (BMP\u20107) would increase local bone formation in the presence of two different adverse stimuli, polyethylene particles, and an oral NSAID. The Drug Test Chamber (DTC) was implanted in the proximal tibia of mature rabbits. The tissue growing into the chamber was exposed to OP\u20101 solution (110 ng\/day), which was infused via an osmotic pump. Infusion of OP\u20101 alone for 6 weeks enhanced local bone formation in the chamber by 80% (<jats:italic>p<\/jats:italic> &lt; 0.05) over infusion of carrier alone. In the presence of polyethylene particles, infusion of OP\u20101 increased local bone formation by 38% (<jats:italic>p<\/jats:italic> &lt; 0.05) over treatment with particles and carrier. Oral administration of NSAID reduced local bone formation by 58% (<jats:italic>p<\/jats:italic> &lt; 0.05); this suppressive effect caused by NSAIDS was completely reversed by the infusion of OP\u20101 (<jats:italic>p<\/jats:italic> &lt; 0.05). These findings underline a potential role for local treatment with OP\u20101 to increase bone formation in the presence of potentially adverse stimuli such as polyethylene wear particles or NSAID use. \u00a9 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006<\/jats:p>","DOI":"10.1002\/jbm.a.30949","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T20:25:41Z","timestamp":1158783941000},"page":"740-746","source":"Crossref","is-referenced-by-count":10,"title":["Effects of local infusion of OP\u20101 on particle\u2010induced and NSAID\u2010induced inhibition of bone ingrowth <i>in vivo<\/i>"],"prefix":"10.1002","volume":"79A","author":[{"given":"T.","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. R.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Mawatari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. B.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,20]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Implant Wear in Total Joint Replacement","author":"Wright T","year":"2001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00003086-198912000-00013","article-title":"The effect of indomethacin, aspirin, and ibuprofen on bone ingrowth into a porous\u2010coated implant","volume":"249","author":"Trancik T","year":"1989","journal-title":"Clin Orthop"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215681"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00079-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.6.963"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003256061"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(03)00003-2"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.3.2.131"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2003.12.017"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30231"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9843"},{"issue":"1","key":"e_1_2_6_13_2","first-page":"S151","article-title":"Osteogenic protein\u20101 (bone morphogenetic protein\u20107) in the treatment of tibial nonunions","volume":"83","author":"Friedlaender GE","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(00)90693-4"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevPhysRehabilMed.v12.i4.30"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200104)55:1<89::AID-JBM120>3.0.CO;2-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200106000-00001"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453679409155227"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0141-5425(88)90029-5"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.81B6.9638"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200009)53:5<475::AID-JBM5>3.0.CO;2-0"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.3000"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10279"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.30949","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.30949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T22:14:14Z","timestamp":1696889654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.30949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,20]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1002\/jbm.a.30949"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.30949","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,20]]}}}