{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:22:01Z","timestamp":1791109321900,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,30]],"date-time":"2007-01-30T00:00:00Z","timestamp":1170115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We developed a cross\u2010linked polyethylene (CLPE) modified with a phospholipid polymer in order to address the serious problem of osteolysis caused by wear particles derived from the polyethylene components of artificial hip joints. Our goal of preventing aseptic loosening could be achieved by avoiding any formation of CLPE wear particles or suppressing the activation of cell systems by the wear particles. We investigated the surface and wear resistance properties of 2\u2010methacryloyloxyethyl phosphorylcholine (MPC) polymer grafted onto the surface of CLPE (CLPE\u2010<jats:italic>g<\/jats:italic>\u2010MPC). The relative density of MPC polymer chains was determined by the P\uf8ffO group index. Generally, polymerization times correspond to the number of polymer chains in radical polymerization. After 3.0 \u00d7 10<jats:sup>6<\/jats:sup> cycles in a hip joint simulator test, the steady wear rates of the untreated CLPE and CLPE\u2010<jats:italic>g<\/jats:italic>\u2010MPC cups with a low P\uf8ffO group index were as high as 4 mg\/10<jats:sup>6<\/jats:sup> cycles; those of the CLPE\u2010<jats:italic>g<\/jats:italic>\u2010MPC cups with high P\uf8ffO group indexes, that is, 0.46 and 0.48, markedly decreased to \u22121.12 and 0.16 mg\/10<jats:sup>6<\/jats:sup> cycles, respectively. Therefore, the grafting of an MPC polymer with high density would be essential in order to maintain the long\u2010term wear resistance of CLPE\u2010<jats:italic>g<\/jats:italic>\u2010MPC as an orthopedic bearing material. \u00a9 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007<\/jats:p>","DOI":"10.1002\/jbm.a.31134","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T23:23:16Z","timestamp":1170458596000},"page":"10-17","source":"Crossref","is-referenced-by-count":65,"title":["Enhanced wear resistance of modified cross\u2010linked polyethylene by grafting with poly(2\u2010methacryloyloxyethyl phosphorylcholine)"],"prefix":"10.1002","volume":"82A","author":[{"given":"Masayuki","family":"Kyomoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Moro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Konno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Takadama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Yamawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Takatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,21]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"46","article-title":"The problem is osteolysis","volume":"311","author":"Harris WH","year":"1995","journal-title":"Clin Orthop"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.79B5.7602"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199906000-00018"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000073343.50837.03"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300001-00003"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100170203"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1054\/arth.2001.20540"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2005.03.033"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.blo.0000096802.78689.45","article-title":"Highly cross\u2010linked polyethylene in cemented THA","volume":"417","author":"Digas G","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200404000-00012"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(03)00341-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2006.03.009"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1233"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1295\/polymj.22.355"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820240809"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820251107"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/la0349673"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00843-7"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1145"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00297-6"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0927-7765(99)00158-7"},{"key":"e_1_2_6_23_2","unstructured":"ISO.Plastics\u2014Film and sheeting\u2014Measurement of water\u2010contact angle of corona\u2010treated films.2004. 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