{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:31:13Z","timestamp":1789947073988,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2008,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fluorescent quantum dots (QDs, semiconductor nanocrystals) have gained increasing attention in the past decade due to their unique optical properties. In this work, we synthesized highly luminescent lipophilic CdSe\/ZnS core\u2010shell QDs under mild conditions, and encapsulated the QDs into solid lipid nanoparticles (SLNs) to prepare fluorescent nanocomposite particles. The transmission electron microscopy image showed that the QDs were nearly monodispersed and uniform with an average diameter of about 4 nm. The fluorescence spectrum of the QDs was symmetric and narrow with an emission maximum at 556 nm. Characterized by photon correlation spectroscopy (PCS) and zeta potential measurement, the nanocomposite particles (QDs\u2010loaded SLNs) exhibit an average particle size of about 90 nm and zeta potential of about \u221228 mV. Fluorescence measurements showed that the encapsulated QDs maintain their high fluorescence and narrow\/symmetric emission spectra. Assembling many QDs in single nanocomposite particle significantly increases the fluorescence signal and the signal\u2010to\u2010background ratio compared to individual QDs. <jats:italic>In vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> imaging indicated that QDs\u2010loaded SLNs were stable and slow to photobleach. These fluorescent QDs\u2010loaded SLNs were biocompatible with fluorescence stability and had good potential in biological imaging applications. The approaches could also be used to encapsulate other optical nanocrystals or magnetic nanoparticles, and allow them to be used under aqueous biological conditions. \u00a9 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008<\/jats:p>","DOI":"10.1002\/jbm.a.31205","type":"journal-article","created":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T22:47:56Z","timestamp":1186008476000},"page":"1018-1025","source":"Crossref","is-referenced-by-count":30,"title":["Preparation and characterization of novel fluorescent nanocomposite particles: CdSe\/ZnS core\u2010shell quantum dots loaded solid lipid nanoparticles"],"prefix":"10.1002","volume":"84A","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhike","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoliang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huibi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangliang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5385.2013"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5385.2016"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104274"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1390"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physe.2004.07.013"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp9535506"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt927"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-1669(02)00282-3"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077194"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl025767z"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp984833b"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp0105488"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/cm9705451"},{"key":"e_1_2_5_15_2","unstructured":"Barbara\u2010Guillem E. Encapsulated CdSe quantum dots and metal oxide nanocrystals in nanometric liposome. US Pat. No. 2 002 001 716A (2001)."},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/la049610t"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/cm000244i"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012043315093"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(00)00087-4"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00105-3"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2004.06.007"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00331-4"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.12.002"},{"key":"e_1_2_5_24_2","unstructured":"HeZK LiangJG XieHY PangDW. The preparation method of CdSe quantum dots. China Pat. No. 1 547 238 (2004)."},{"key":"e_1_2_5_25_2","unstructured":"PangDW XieHY HouAX. The preparation method of CdSe\/ZnS and CdSe\/CdS core\u2010shell quantum dots. China Pat. No. 1 174 080 (2004)."},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/js950164r"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp020170t"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl034086g"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0927-7757(01)01078-0"},{"key":"e_1_2_5_30_2","unstructured":"ChanWCW.Luminescent quantum dots for multiplexed biological detection and imaging. PhD Thesis. Department of Chemistry Indiana University;2001."},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp035361q"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp048406b"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.31205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.31205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T22:02:00Z","timestamp":1697148120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.31205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,3,15]]}},"alternative-id":["10.1002\/jbm.a.31205"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.31205","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}