{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:15:57Z","timestamp":1770992157781,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aseptic loosening remains the primary cause of failure in total joint arthroplasty. Implant\u2010derived particles are thought to be a main cause of osteolysis that leads to failure of total joint arthroplasty. The nervous system has been implicated in the etiology and pathogenesis of joint diseases. Substance P (SP) immunoreactive nerve fibers have been detected in the pseudomembrane and pseudocapsular tissues of aseptic loose hip prostheses, suggesting that SP might be involved in the process of aseptic loosening. Fibroblasts are abundant in periprosthetic membrane. Neuropeptides are able to modulate cytokine production by fibroblasts. In this study, we isolated fibroblasts from periprosthetic membrane at the time of revision hip arthroplasty performed because of aseptic loosening. Fibroblasts were stimulated with titanium (Ti) particles or SP. Prostaglandin (PG) E2 and interleukin\u20106 (IL\u20106) assays were performed using enzyme\u2010linked immunosorbent assay kit. PGE2 and IL\u20106 secretion by fibroblasts have been significantly increased in the presence of Ti particles or SP. Moreover SP caused significant increase in PGE2 and IL\u20106 production by Ti particles\u2010stimulated fibroblasts. Thus, SP and Ti particles acted synergistically to increase PGE2 and IL\u20106 secretion in fibroblasts from periprosthetic membrane. \u00a9 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007<\/jats:p>","DOI":"10.1002\/jbm.a.31318","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T16:59:15Z","timestamp":1177088355000},"page":"401-406","source":"Crossref","is-referenced-by-count":7,"title":["Substance P augments PGE2 and IL\u20106 production in titanium particles\u2010stimulated fibroblasts from hip periprosthetic 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