{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:19:09Z","timestamp":1791299949006,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T00:00:00Z","timestamp":1181260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study the presence both of the <jats:italic>ica<\/jats:italic> genes, encoding for biofilm exopolysaccharide production, and the insertion sequence IS<jats:italic>256<\/jats:italic>, a mobile element frequently associated to transposons, was investigated in relationship with the prevalence of antibiotic resistance among <jats:italic>Staphylococcus epidermidis<\/jats:italic> strains. The investigation was conducted on 70 clinical isolates derived from orthopedic implant infections. Among the clinical isolates investigated a dramatic high level of association was found between the presence of <jats:italic>ica<\/jats:italic> genes as well as of IS<jats:italic>256<\/jats:italic> and multiple\u2010resistance to all the antibiotics tested (oxacillin, penicillin, gentamicin, erythromycin, clindamycin, chloramphenicol, sulfamethoxazole + trimethoprim, ciprofloxacin, vancomycin). Noteworthy, a striking full association between the presence of IS<jats:italic>256<\/jats:italic> and resistance to gentamicin was found, being none of the IS<jats:italic>256<\/jats:italic>\u2010negative strain resistant to this antibiotic. This association is probably because of the link of the corresponding aminoglycoside\u2010resistance genes, and IS<jats:italic>256<\/jats:italic>, often co\u2010existing within the same staphylococcal transposon. In conclusion, in orthopedics, the presence of <jats:italic>ica<\/jats:italic> genes and that of IS<jats:italic>256<\/jats:italic> in <jats:italic>S. epidermidis<\/jats:italic> genome should both be considered as informative markers of clinically relevant strains equipped with greatest and broadest resistance potential to survive to medical treatments. \u00a9 2007 Wiley Periodicals, Inc. 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