{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:05:26Z","timestamp":1790208326959,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,7,6]],"date-time":"2007-07-06T00:00:00Z","timestamp":1183680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Auricular reconstruction remains a major challenge facing reconstructive surgeons owing to the complexity of autogenous transplants. In this study, the development of a three\u2010dimensional custom\u2010made polyurethane (PU) auricular implant with hydroxyapatite (HA) coating is described. The PU implant was produced by computerized tomography (CT) scanning and indirect rapid prototyping. To improve the physiological response of the implant, the PU prototype was coated with a microrough, homogenous layer of HA by a novel solvent\u2010compression coating method. Bioactivity of the HA coated PU substrates was confirmed by apatite formation on the HA coating after 9 days in revised simulated body fluid (pH 7.4). Adhesion strength of the HA coating to the PU surface using the tensile pull\u2010off test revealed partial failure of the coating with an average tensile strength of 1.6 MPa. As an initial stage indication of cytocompatibility for a soft tissue application, <jats:italic>in vitro<\/jats:italic> cell culturing on the HA\u2010coated PU substrates using Graham 293 fibroblast cells was performed. After 24 and 72 h, the HA coated surfaces displayed significantly higher cell numbers and metabolically active cells compared with the virgin uncoated PU surfaces. This indicates that HA coated PU surfaces are cytocompatible towards fibroblasts and could potentially be applied to auricular cartilage tissue replacement. \u00a9 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008<\/jats:p>","DOI":"10.1002\/jbm.a.31465","type":"journal-article","created":{"date-parts":[[2007,7,6]],"date-time":"2007-07-06T20:17:20Z","timestamp":1183753040000},"page":"475-482","source":"Crossref","is-referenced-by-count":26,"title":["Hydroxyapatite\u2010coated polyurethane for auricular cartilage replacement: An <i>in vitro<\/i> study"],"prefix":"10.1002","volume":"84A","author":[{"given":"Avashnee","family":"Chetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tenille","family":"Steynberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Moolman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Nilen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Joubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200207000-00041"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200104150-00024"},{"key":"e_1_2_6_4_2","unstructured":"MSAC application 1024.Total ear reconstruction Assessment report Commonwealth of Australia 2000."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900060020003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-3538(00)00241-4"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00350-8"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00501-5"},{"key":"e_1_2_6_9_2","unstructured":"Noveon The Speciality Chemicals Innovator\u2122. 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In Proceedings of the Second Annual Conference with International Participation on Rapid Technologies Rapid Product Development Association of South Africa Stellenbosch South Africa 14\u201315 November2001. p66\u201372."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/KEM.192-195.47"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008900428325"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(86)90314-3"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(94)90034-5"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.11.022"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/KEM.240-242.3"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v004a01"},{"key":"e_1_2_6_22_2","series-title":"Introduction to Polymeric Biomaterials","first-page":"267","author":"Saad B","year":"2003"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.01.037"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.31465","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.31465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.a.31465","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.31465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T21:12:50Z","timestamp":1693948370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.31465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,6]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1002\/jbm.a.31465"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.31465","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,6]]}}}