{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:05:23Z","timestamp":1790834723191,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T00:00:00Z","timestamp":1192492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have developed chitosan nonwoven micro\/nanofiber mesh tubes and examined the effects of their mechanical strength and permeability on nerve regeneration. Chitosan nano\/microfibrous tubes with a deacetylation rate (DAc) of 78% or 93% were prepared by electrospinning. A chitosan film tube with a DAc of 93% was also fabricated and combined with the nano\/microfibrous tubes to form bilayered tubes with a nano\/microfiber mesh inner structure and a film outer layer. Nano\/microfiber mesh tubes with a DAc of 78% or 93%, bilayered tubes with a nano\/microfiber mesh inner structure with a DAc of 78% or 93% and a film outer layer with a DAc of 93%, and film tubes with a DAc of 93% were each tested as bridge grafts into injured rat sciatic nerve. Isografting was performed as a control. Although the functional recovery of motor activity was delayed in each group, sensory function reemerged first in the isograft group followed by the group receiving nano\/microfiber mesh tubes with a DAc of 93%. Histological analysis was consistent with these results. The chitosan nano\/microfiber mesh tubes with a DAc of 93% have sufficient mechanical properties to preserve tube space, provide a better scaffold for cell migration and attachment, and facilitate humoral permeation to enhance nerve regeneration. \u00a9 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008<\/jats:p>","DOI":"10.1002\/jbm.a.31536","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T16:16:55Z","timestamp":1192551415000},"page":"557-566","source":"Crossref","is-referenced-by-count":41,"title":["Influences of mechanical properties and permeability on chitosan nano\/microfiber mesh tubes as a scaffold for nerve regeneration"],"prefix":"10.1002","volume":"84A","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuko","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Shinomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuiro","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzo","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00167-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200104)55:1<20::AID-JBM30>3.0.CO;2-F"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(96)00167-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-8166(84)90020-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00633-6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2003.07208.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.09.003"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(98)00209-9"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820280515"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1996.2.241"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3160001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/7\/3\/009"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-3861(99)00068-3"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/masy.19981270119"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.06.051"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408690390826473"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00326-4"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00121-6"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/pc.10340"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00363369"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30432"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.31536","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.31536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.a.31536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.31536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T21:13:07Z","timestamp":1693948387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.31536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,16]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1002\/jbm.a.31536"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.31536","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,16]]}}}