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The objective of this study was to investigate amphiphilic block copolymer micelles of poly(ethylene oxide)\u2010<jats:italic>b<\/jats:italic>\u2010poly(\u03f5\u2010caprolactone) (PEO\u2010PCL) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. Curcumin\u2010loaded PEO\u2010PCL micelles were prepared by a cosolvent evaporation technique. PEO\u2010PCL micelles were able to solubilize curcumin effectively, protect the encapsulated curcumin from hydrolytical degradation in physiological matrix, and control the release of curcumin over a few days. The characteristics of resultant micelles were found to depend on the polymerization degrees of \u03f5\u2010caprolactone. Among different PEO\u2010PCL micelles, PEO<jats:sub>5000<\/jats:sub>\u2010PCL<jats:sub>24500<\/jats:sub> was the most efficient in solubilizing curcumin while PEO<jats:sub>5000<\/jats:sub>\u2010PCL<jats:sub>13000<\/jats:sub> was the best carrier in reducing its release rate. PEO\u2010PCL micelle\u2010encapsulated curcumin retained its cytotoxicity in B16\u2010F10, a mouse melanoma cell line, and SP\u201053, Mino, and JeKo\u20101 human mantle cell lymphoma cell lines. These results demonstrated the potential of PEO\u2010PCL micelles as an injectable formulation for efficient solubilization, stabilization, and controlled delivery of curcumin. \u00a9 2007 Wiley Periodicals, Inc. 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