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The results of TGA ascribed that [Cu(II)\u2010PoU<jats:sub>A<\/jats:sub>] show better heat resistant properties than other metals chelated polyurea. The antibacterial activities of all the synthesized polymers were determined using the shaking flask method, where 30 mg\/mL concentrations of each compound were tested against 10<jats:sup>5<\/jats:sup> CFU\/mL solutions of <jats:italic>S. aureus, E. coli, B. subtillis, S. typhi<\/jats:italic>. The number of viable bacteria was calculated by using the spread plate method on agar plates and the number of viable bacteria was counted after 24 h of incubation period at 37\u00b0C. All the polymers showed good antibacterial activity. The Cu(II) chelated polyurea show higher zone of inhibition then other due to higher stability constant and may be used in biomedical applications. \u00a9 2008 Wiley Periodicals, Inc. 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