{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:22:28Z","timestamp":1791220948494,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T00:00:00Z","timestamp":1207094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2009,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The function of a photocrosslinked poly(propylene fumarate) (PPF)\/poly(<jats:italic>N<\/jats:italic>\u2010vinyl pyrrolidone) (PVP) matrix for the sustained release of three ophthalmic model drugs, acetazolamide (AZ), dichlorphenamide (DP), and timolol maleate (TM), was investigated. The drugs differ in molecular weight and degree of dissociation in aqueous environments; both are parameters that significantly influence drug diffusivity. AZ, DP, and TM\u2010loaded cylindrical rods (10 mm length, 0.6 mm diameter) were fabricated by photoinduced cross\u2010copolymerization of PPF and <jats:italic>N<\/jats:italic>\u2010vinyl pyrrolidone (NVP) in molds. The released amounts of AZ, DP, TM, and NVP were determined by high\u2010performance liquid chromatography (HPLC). The effects of drug properties and loading on the release kinetics were investigated. The <jats:italic>in vitro<\/jats:italic> release of AZ, DP, and TM was well sustained from the polymer matrices over a period of \u223c210, 270, and 250 days, respectively. The release kinetics correlated with the HPLC retention profiles of the different drugs. Following a small initial burst release (&lt;10%), a dual modality release controlled by diffusion and bulk erosion was found for all drugs. Drug release rates of up to 4 \u03bcg\/day were reached. Matrix drug loading generally affected the extent of the burst release, release kinetics, as well as the matrix water content and matrix degradation that were determined gravimetrically. Microcomputed tomography was used to image structural and dimensional changes of the devices. A preliminary rabbit implantation study revealed promising ocular biocompatibility of drug\u2010free PPF\/PVP matrices. All results indicate the potential of photocrosslinked PPF\u2010based matrices as polymeric carriers for long\u2010term ophthalmic drug delivery. \u00a9 2008 Wiley Periodicals, Inc. 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