{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:43Z","timestamp":1791330943701,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T00:00:00Z","timestamp":1213056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Perforated tympanic membranes (TM) and otitis media can be managed with a paper patch or tympanoplasty. However, a paper patch is not biocompatible and tympanoplasty requires complex aseptic surgical procedures. A novel biocompatible patch with a water\u2010insoluble chitosan as the main component was prepared. Optimal mechanical characteristics of a water\u2010insoluble chitosan patch scaffold (CPS) was \u223c40 \u03bcm in thickness, 7 MPa in tensile strength, and 107% in percent elongation, even though the characteristics varied significantly depending on the concentrations of chitosan and glycerol. SEM of the CPSs showed a very smooth surface as compared with that of the paper patches. These CPSs showed no cytotoxicity and had a stimulating effect on the proliferation of TM cells in <jats:italic>in vitro<\/jats:italic> study. In <jats:italic>in vivo<\/jats:italic> study, 4 (21.1%) and 17 (89.5%) TMs out of 19 adult rats with CPSs showed no perforations at 1 and 2 weeks, respectively. However, left control TMs showed healing of 0 (0%) at 1 week and 18 (94.7%) at 2 weeks. TEM findings of regenerated eardrums using CPSs showed thinner, smoother, and more compact tissues than spontaneously healed eardrums. A CPS was more effective than spontaneous healing to repair traumatic TM perforations. \u00a9 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009<\/jats:p>","DOI":"10.1002\/jbm.a.32119","type":"journal-article","created":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T17:08:18Z","timestamp":1213117698000},"page":"446-455","source":"Crossref","is-referenced-by-count":44,"title":["Development of water\u2010insoluble chitosan patch scaffold to repair traumatic tympanic membrane perforations"],"prefix":"10.1002","volume":"90A","author":[{"given":"Jang Ho","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon\u2010Ho","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki 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