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The hydrophobicity, crystallinity, mechanical properties, and wear performance of the UHMWPE\u2010E2 were characterized compared with the control UHMWPE. The thermal analysis and Fourier Transform Infrared Spectroscopy results demonstrated that the hot press processing would not alter the functional groups of E2 in this study. There were no significant differences in the hydrophobicity and crystallinity between the UHMWPE\u2010E2 and UHMWPE. The UHMWPE\u2010E2 showed satisfying mechanical properties, including ultimate tensile strength (47.2 \u00b1 3.6 MPa), yield strength (25.0 \u00b1 0.6 MPa) and elongation at break (320 \u00b1 25.5 %), which were similar with the control UHMWPE. The friction coefficients and worn scars were similar between the UHMWPE\u2010E2 and the control UHMWPE. The wear mechanism of the UHMWPE\u2010E2 and UHMWPE both were abrasive wear under dry friction. The UHMWPE\u2010E2 possesses the approving mechanical properties and wear performance compared with the control UHMWPE, which might be used as the potential implanted drug carrier to prevent the particle\u2010induced osteolysis in joint replacements. \u00a9 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009<\/jats:p>","DOI":"10.1002\/jbm.a.32120","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T17:25:20Z","timestamp":1213809920000},"page":"496-505","source":"Crossref","is-referenced-by-count":8,"title":["UHMWPE carrying estradiol to treat the particle\u2010induced osteolysis\u2014Processing and 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