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However, systemic administration of CyA could create serious adverse effects. Therefore, it is our long\u2010term goal to test the hypothesis that the controlled local release of CyA from a polymeric vascular wrap would prevent the development of IH. To test this hypothesis, we developed a controlled release polymeric ring that could be placed around anastomotic sites to deliver therapeutic drugs locally. The ring is a composite polymeric device consisting of poly(<jats:sc>DL<\/jats:sc>\u2010lactide\u2010<jats:italic>co<\/jats:italic>\u2010glycolide) (PLGA) microspheres embedded in a poly(ethylene glycol) hydrogel. Several <jats:italic>in vitro<\/jats:italic> studies were conducted to evaluate the effects of different sterilization procedures on the properties of the device. It was determined that gamma sterilization was the preferred sterilization method of choice for this device. <jats:italic>In vivo<\/jats:italic> studies were conducted on a swine model to evaluate the biocompatibility of the ring. The histological findings of the ring implants at 2 and 4 weeks demonstrate the biocompatibility of this device. \u00a9 2009 Wiley Periodicals, Inc. 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