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By selecting optimized processing conditions, numerous blend scaffolds were already built with well\u2010controlled porous structures and approximately similar pore parameters. The interactions between these scaffolds and the rat osteoblasts were further investigated by measuring the adhesion, proliferation, and morphologies of cells as well as the corresponding alkaline phosphatase activity during various culture periods <jats:italic>in vitro<\/jats:italic>. Data collected from different measurements reflected that by incorporating an appropriate amount of chitosan component, the resultant blend scaffolds could improve the adhesion and growth of osteoblasts and exert a significant impact on the osteoblastic phenotype. \u00a9 2009 Wiley Periodicals, Inc. 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