{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T12:36:05Z","timestamp":1719232565634},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,7,7]],"date-time":"2009-07-07T00:00:00Z","timestamp":1246924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of the study was to evaluate the distributions of (1) cells expressing the contractile actin isoform, \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) and (2) a lubricating and antiadhesion glycoprotein, lubricin, in the tissue around loose joint replacement prostheses in human subjects. Periprostehtic tissue resected at revision arthroplasty of noncemented glenoid components of total shoulder arthroplasties was obtained from 10 patients. Samples of periprosthetic tissue were stained with monoclonal antibodies to \u03b1\u2010SMA and lubricin. \u03b1\u2010SMA was found in cells, principally of fibroblast morphology, in many of the fields of view (FOVs) in samples from all patients. Moderate correlations were observed between the percentage of FOVs containing \u03b1\u2010SMA\u2010expressing cells and the percentages of FOVs containing polyethylene (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.79) and metallic (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.75) particles. Lubricin was identified (1) as a discrete layer on the surface, (2) within the extracellular matrix, and (3) intracellularly. These lubricin\u2010positive features were found in samples from all patients. Strong correlations were noted between the percentages of FOVs with matrix and intracellular lubricin staining (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.97) and between the percentages of FOVs with surface and matrix staining for lubricin (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.96). Having established the presence of \u03b1\u2010SMA and lubricin in periprosthetic tissue, hypotheses regarding their role in the development and persistence of periprosthetic tissue can be synthesized for future study: for example, \u03b1\u2010SMA\u2010enabled contracture of the fibrous periprosthetic tissue results in its densification, and lubricin\u2010coated surfaces interfere with integrative repair processes necessary for resorption and remodeling. \u00a9 2009 Wiley Periodicals, Inc. 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