{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T03:32:22Z","timestamp":1781235142911,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T00:00:00Z","timestamp":1258070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2010,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Current orthopedic implants have several problems that include poor osseointegration for extended periods of time, stress shielding and wear debris\u2010associated bone cell death. In addition, numerous patients receive orthopedic implants as a result of bone cancer resection, yet current orthopedic materials were not designed to prevent either the occurrence or reoccurrence of cancer. The objective of this <jats:italic>in vitro<\/jats:italic> study was to create a new biomaterial which can both restore bone and prevent cancer growth at the implant\u2010tissue interface. Elemental selenium was chosen as the biologically active agent in this study because of its known chemopreventive and chemotherapeutic properties. It was found that when selenite salts were reduced by glutathione in the presence of an immersed titanium substrate, elemental selenium nucleated and grew into adherent, hemispherical nanoclusters that formed a nanostructured composite surface. Three types of surfaces with different selenium surface densities on titanium were fabricated and confirmed by SEM images, AFM, and XPS profiles. Compared to conventional untreated titanium, a high\u2010density selenium\u2010doped surface inhibited cancerous bone cell proliferation while promoting healthy bone cell functions (including adhesion, proliferation, alkaline phosphatase activity and calcium deposition). These findings showed for the first time the potential of selenium nanoclusters as a chemopreventive titanium orthopedic material coating that can also promote healthy bone cell functions. \u00a9 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010<\/jats:p>","DOI":"10.1002\/jbm.a.32631","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T19:51:04Z","timestamp":1258141864000},"page":"1417-1428","source":"Crossref","is-referenced-by-count":63,"title":["Titanium surfaces with adherent selenium nanoclusters as a novel anticancer orthopedic material"],"prefix":"10.1002","volume":"93A","author":[{"given":"Phong A.","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Love","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Hurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,13]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"1","article-title":"Joint replacements become more routine here","volume":"19","author":"Crompton K.","year":"2004","journal-title":"J Business\u2010Spokane"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199905)45:2<75::AID-JBM1>3.0.CO;2-P"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2377(01)27005-7"},{"key":"e_1_2_7_5_2","first-page":"460","volume-title":"Orthopedic Basic Science","author":"Kaplan FS","year":"1994"},{"key":"e_1_2_7_6_2","first-page":"127","volume-title":"Orthopedic Basic Science","author":"Kaplan FS","year":"1994"},{"key":"e_1_2_7_7_2","unstructured":"American Cancer Society. Cancer Statistics.http:\/\/www.cancer.org\/docroot\/stt\/sh\u20100\u20102008 asp?sitearea=stt&level=1 Accessed Feb 20 2008."},{"key":"e_1_2_7_8_2","first-page":"307","volume-title":"Cancer Nanotechnology","author":"Miller D","year":"2007"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-2156-0","volume-title":"Biomaterials\u2010An Introduction","author":"Park JB","year":"1992"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00075-2"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00020-4"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.12.002"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(20000905)51:3<475::AID-JBM23>3.0.CO;2-9"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2001.9134"},{"key":"e_1_2_7_15_2","volume-title":"Minerals in Human Nutrition","author":"Mcdowell L.","year":"2003"},{"key":"e_1_2_7_16_2","volume-title":"The Role of Selenium in Nutrition","author":"Combs GF","year":"1986"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1991.9937427"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00014-X"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0048-9697(99)00526-4"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540240035027"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.1.80"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1998.00630.x"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2005467"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.3.513"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910630322"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(97)00497-7"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)00103-2"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.9.1903"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207683"},{"key":"e_1_2_7_30_2","first-page":"1171","article-title":"Selenium effects on prostate cell growth","volume":"9","author":"Menter DG","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC401_4"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30423"},{"key":"e_1_2_7_33_2","first-page":"99","article-title":"Metabolism of subtoxic levels of selenium in animals and humans","volume":"26","author":"Whanger P","year":"1996","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2004.03.031"},{"key":"e_1_2_7_35_2","first-page":"374","article-title":"Synthesis of selenium nanoparticles in aqueous solutions of poly(vinylpyrrolidone) and morphological characteristics of the related nanocomposites","volume":"45","author":"Kopeikin V","year":"2003","journal-title":"Polym Sci Ser A"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2005.02.023"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00231.x"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00123-6"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.018"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006767007547"},{"key":"e_1_2_7_41_2","first-page":"275","volume-title":"Handbook of X\u2010ray photoelectron spectroscopy: A reference book of standard spectra for identification and interpretation of xps data","author":"Moulder JF","year":"1992"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520150103"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:JRNC.0000028220.00481.8e"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31799"},{"key":"e_1_2_7_45_2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1158\/1055-9965.771.13.5","article-title":"Selenium and lung cancer:A quantitative analysis of heterogeneity in the current epidemiological literature","volume":"13","author":"Zhuo H","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_46_2","first-page":"215","volume-title":"Nutritional Oncology","author":"Combs G","year":"1999"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.11.1845"},{"key":"e_1_2_7_48_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/jn\/124.2.172","article-title":"Dietary selenite modifies glutathione metabolism and 7,12\u2010dimethylbenz(a)anthracene conjugation in rats","volume":"124","author":"Liu JZ","year":"1994","journal-title":"J Nutr"},{"key":"e_1_2_7_49_2","first-page":"2826","article-title":"Mechanism of benzylselenocyanate inhibition of azoxymethane\u2010induced colon carcinogenesis in F344 rats","volume":"51","author":"Fiala ES","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi077"},{"key":"e_1_2_7_51_2","first-page":"389","volume-title":"Nutrition and Cancer Prevention: Investigating the Role of Micronutrients","author":"Combs G.","year":"1989"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00848a029"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr60090a001"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1089\/10763270152044152"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2005.008"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00087-X"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.32631","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.32631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:52:52Z","timestamp":1697295172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.32631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,13]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,6,15]]}},"alternative-id":["10.1002\/jbm.a.32631"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.32631","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,13]]}}}