{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:41:16Z","timestamp":1791304876833,"version":"4.3.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Distinction between the two major complications of total hip replacement surgery, septic bacterial culture\u2010positive and aseptic bacterial culture\u2010negative osteolysis and loosening, is difficult due to the eventual role of bacterial remnants and biofilms, which are recognized by cells provided by toll\u2010like receptors (TLRs) of the innate immune system. It was hypothesized that cell typing and TLR mapping might provide new information on the pathomechanisms of loosening. To test this hypothesis, septic (<jats:italic>n<\/jats:italic> = 10) and aseptic (<jats:italic>n<\/jats:italic> = 5) interface tissue as well as mildly inflamed osteoarthritic synovial membrane (<jats:italic>n<\/jats:italic> = 5) samples were characterized and compared using antibodies against several cell line\u2010specific markers, including fibroblast, monocyte\/macrophage, T cell, B cell, plasma cell and neutrophil markers, and TLRs. In osteoarthritic synovium, TLR\u2010positive cells were restricted to surface tissues and only few inflammatory cells were detected, whereas aseptic interface was heavily infiltrated with monocyte\/macrophages, which were also the major TLR\u2010positive cell type rendering the tissue reactive to TLR ligands. Interestingly, septic cases contained also neutrophil and lymphocyte infiltrates of which especially B\u2010cell infiltrates might be clinically useful in discriminating the two major complications of the joint replacement surgery. \u00a9 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010<\/jats:p>","DOI":"10.1002\/jbm.a.32674","type":"journal-article","created":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T16:15:37Z","timestamp":1265040937000},"page":"84-92","source":"Crossref","is-referenced-by-count":31,"title":["Profile of toll\u2010like receptor\u2013positive cells in septic and aseptic loosening of total hip arthroplasty 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