{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:52:05Z","timestamp":1790196725977,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T00:00:00Z","timestamp":1268006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A nonwoven ceramic\/polymer composite fabric composed of randomly mixed bioactive and fast degradable CaO\u2010SiO<jats:sub>2<\/jats:sub> gel fibers and biodegradable poly(\u03b5\u2010caprolactone) (PCL) fibers is prepared with a simultaneous electrospinning method for potential use as bone grafting materials. A 17% PCL solution is prepared using 1,1,3,3\u2010hexafluoro\u20102\u2010propanol as the solvent, whereas the CaO\u2010SiO<jats:sub>2<\/jats:sub> gel solution is prepared via a condensation reaction following the hydrolysis of tetraethyl orthosilicate. PCL and CaO\u2010SiO<jats:sub>2<\/jats:sub> gel solutions are spun simultaneously with two separate nozzles. As controls, pure PCL and CaO\u2010SiO<jats:sub>2<\/jats:sub> gel nonwoven fabrics are also made by the same methods. The three nonwoven fabrics were exposed to simulated body fluid for 1 week and resulted in the deposition of a layer of apatite crystals on the surfaces of both the CaO\u2010SiO<jats:sub>2<\/jats:sub> gel and PCL\/CaO\u2010SiO<jats:sub>2<\/jats:sub> gel composite fabrics, but not on the PCL fabric. A tensile strength test showed that the fracture behavior of the CaO\u2010SiO<jats:sub>2<\/jats:sub> gel fabric was brittle, that of the PCL fabric was ductile\u2010tough, and that of the PCL\/CaO\u2010SiO<jats:sub>2<\/jats:sub> gel composite fabric was intermediate between that of the CaO\u2010SiO<jats:sub>2<\/jats:sub> gel and PCL fabrics. Our <jats:italic>in vivo<\/jats:italic> tests showed that the CaO\u2010SiO<jats:sub>2<\/jats:sub> gel and PCL\/CaO\u2010SiO<jats:sub>2<\/jats:sub> gel composite fabrics had good osteoconductivity and fast degradation rates in calvarial defects of New Zealand white rabbits within 4 weeks, in contrast to the pure PCL fabric. Together, these results suggest that the composite fabric composed of PCL and CaO\u2010SiO<jats:sub>2<\/jats:sub> gel fibers must have a great potential for use in applications such as bone grafting because of its good osteoconductivity and adequate mechanical properties. \u00a9 2010 Wiley Periodicals, Inc. 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