{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:49:37Z","timestamp":1777517377576,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T00:00:00Z","timestamp":1270684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, three kinds of two\u2010component adhesive glues were prepared, namely, gel\u2010dext glue made from modified gelatin and dextran, gel\u2010HES glue made from modified gelatin and hydroxyethyl starch (HES), and chit\u2010dext glue made from chitosan and modified dextran. Upon mixing the two\u2010component solution together crosslinking occurred and a gel formed in several seconds, which would seal the wound tissue and stop the bleeding. The adhesive ability of those three prepared glues was evaluated <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> separately by measuring the bonding strength to two piece of porcine skin and the adhesive strength after sealing the skin incisions on the back of rat. Fibrin glue was used as comparing. Gel\u2010dext glue and gel\u2010HES glue shown higher bonding strength and adhesive strength than chit\u2010dext glue and fibrin glue. Histology test of incision tissues given by both HE and MTC methods, the former shown that gel\u2010dext and gel\u2010HES glues, like fibrin glue, have only normal initial inflammation to skin tissue, which almost disappear from 9 days but chit\u2010dext glue seams have heaver inflammation, which may last to 12 days; the later shown gel\u2010dext and gel\u2010HES glues similar to fibrin glue, can heal the wound fast than that of chit\u2010dext glue. The hemostatic ability for gel\u2010HES glue was also tested on a cut liver of rat, which depend on the gel formation speed when the two\u2010composite solutions were mixed together. \u00a9 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010<\/jats:p>","DOI":"10.1002\/jbm.a.32788","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T18:58:49Z","timestamp":1270753129000},"page":"326-332","source":"Crossref","is-referenced-by-count":38,"title":["A tissue adhesives evaluated <i>in vitro<\/i> and <i>in vivo<\/i> analysis"],"prefix":"10.1002","volume":"94A","author":[{"given":"Xiumei","family":"Mo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Ikada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,8]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Tissue Adhesives in Wound Care","author":"Quinn JV","year":"1998"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/028418519003100103","article-title":"Embolization of cerebral arteriovenous malformations with bucrylate: Experience in a first series of 29 patients","volume":"31","author":"Berthelsen B","year":"1991","journal-title":"Acta Radiol"},{"key":"e_1_2_5_4_2","first-page":"263","article-title":"Surgery of an acute dissection with GRF biological glue: Atwelve\u2010year experience","volume":"31","author":"Bachet J","year":"1990","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_5_5_2","first-page":"3","volume-title":"Surgical Adhesives and Sealants Current Technology and Applications","author":"Spotnitz WD","year":"1996"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38760-8"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0022-5223(19)38254-6","article-title":"Use of biological glue in acute aortic dissection. 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