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For this purpose, a series of chitosan\/hydroxyapatite composites has been synthesized in aqueous medium from chitosan solution and soluble precursor salts by a one step coprecipitation method. A study of <jats:italic>in vivo<\/jats:italic> behavior of the materials was then performed using model linear rats. Cylindrical\u2010shaped rods made of the chitosan\/hydroxyapatite composite material were implanted into tibial bones of the rats. After 5, 10, 15, and 24 days of implantation, histological and histo\u2010morphometric analyses of decalcified specimens were performed to evaluate the stages of biodegradation processes. Calcified specimens were examined by scanning electron microscopy with X\u2010ray microanalysis to compare elemental composition and morphological characteristics of the implant and the bone during integration. Porous chitosan\/hydroxyapatite scaffolds have shown osteoconductive properties and have been replaced in the <jats:italic>in vivo<\/jats:italic> experiments by newly formed bone tissue. \u00a9 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 2011.<\/jats:p>","DOI":"10.1002\/jbm.a.33017","type":"journal-article","created":{"date-parts":[[2011,1,25]],"date-time":"2011-01-25T16:02:30Z","timestamp":1295971350000},"page":"639-647","source":"Crossref","is-referenced-by-count":73,"title":["Characterization and <i>in vivo<\/i> evaluation of chitosan\u2010hydroxyapatite bone scaffolds made by one step coprecipitation method"],"prefix":"10.1002","volume":"96A","author":[{"given":"Sergei N.","family":"Danilchenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana V.","family":"Kalinkevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksim V.","family":"Pogorelov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksei N.","family":"Kalinkevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly M.","family":"Sklyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana G.","family":"Kalinichenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyacheslav Y.","family":"Ilyashenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim V.","family":"Starikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina I.","family":"Bumeyster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly Z.","family":"Sikora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid F.","family":"Sukhodub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v011a06"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00115-7"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200104)55:1<20::AID-JBM30>3.0.CO;2-F"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.01.051"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00582-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1515\/9781501509636-014","volume-title":"Phosphates: Geochemical, Geobiological, and Materials Importance. 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