{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:23Z","timestamp":1786977863502,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T00:00:00Z","timestamp":1317686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The use of biomaterials as implantable thermoseeds under the action of an external magnetic field is a very interesting methodology to focus the heat into the target tumors as osteosarcoma. In this study, biocompatible and bioactive G15GC85 thermoseeds, tailored through the combination of sol\u2013gel glasses (G) with a magnetic glass ceramic (GC), were used to induce hyperthermia on cultured human osteosarcoma cells after exposition to alternating magnetic field (MF, 100 kHz\/200 Oe). G15GC85 magnetic glass\u2013glass ceramic thermoseeds induced\n                    <jats:italic>in vitro<\/jats:italic>\n                    effective hyperthermia with drastic reduction in proliferation of human osteosarcoma Saos\u20102 cells and high increase of apoptotic cells after two 40 min consecutive sessions of MF. Deep cell morphology alterations were observed after this hyperthermic treatment, and the proteomic analysis revealed modification of gamma actin molecular properties related to cytoskeleton alterations. These results indicate that G15GC85 thermoseeds allow to induce\n                    <jats:italic>in vitro<\/jats:italic>\n                    effective hyperthermia on human osteosarcoma cells. \u00a9 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.33229","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T07:10:54Z","timestamp":1317712254000},"page":"64-71","source":"Crossref","is-referenced-by-count":23,"title":["<i>In vitro<\/i>\n                    evaluation of glass\u2013glass ceramic thermoseed\u2010induced hyperthermia on human osteosarcoma cell line"],"prefix":"10.1002","volume":"100A","author":[{"given":"Mar\u00eda","family":"Alcaide","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Ram\u00edrez\u2010Santill\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Feito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"de la Concepci\u00f3n 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