{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:41:54Z","timestamp":1778625714446,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T00:00:00Z","timestamp":1323648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tympanic membrane (TM) perforation is still one of the most common otology complications. New designs of biomaterials, and lately tissue\u2010engineered composites and grafts, have thoroughly revolutionized the management of TM perforation. In this study, we examined a biologically modified collagen\u2010immobilized polydimethyl siloxane patch to repair TM perforation. <jats:italic>In vitro<\/jats:italic> potential of the aforementioned patch as a scaffold to support fibroblast cell growth and adhesion was assessed. An <jats:italic>in vivo<\/jats:italic> assay of the patch for initiating repair of TM perforations also was investigated. <jats:italic>In vitro<\/jats:italic> assay showed that the patch has significantly increased cell adhesion and growth in comparison with unmodified ones (<jats:italic>p<\/jats:italic> &lt; 0.05). <jats:italic>In vivo<\/jats:italic> study also showed an overall closure rate of TM perforation of 70% and an average gain of 15.75 \u00b1 4.29 dB in air\u2010bone gap. This study shows that the preliminary <jats:italic>in vivo<\/jats:italic> evaluation of a modified siloxane patch in humans had promising results and is comparable to existing biomaterial patches. \u00a9 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.<\/jats:p>","DOI":"10.1002\/jbm.a.33293","type":"journal-article","created":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T05:53:47Z","timestamp":1323669227000},"page":"549-553","source":"Crossref","is-referenced-by-count":26,"title":["Collagen\u2010immobilized patch for repairing small tympanic membrane perforations: <i>In vitro<\/i> and <i>in vivo<\/i> assays"],"prefix":"10.1002","volume":"100A","author":[{"given":"Mohammad","family":"Farhadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Mirzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atefeh","family":"Solouk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alimohamad","family":"Asghari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Jalessi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Ghanbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parin","family":"Yazdanifard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1473-y"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.07.0l4"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.746"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0030-6665(20)32588-3","article-title":"Tympanoplasty: A chronological history","volume":"10","author":"Glasscock ME","year":"1977","journal-title":"Otolaryngol Clin North Am"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948008900407"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.07.008"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00565.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2009.10.007"},{"key":"e_1_2_5_10_2","first-page":"301","article-title":"Perichondrium\/cartilage composite graft for repairing large tympanic membrane perforations and hearing improvement","volume":"123","author":"Chen XW","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pi.783"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/app.27281"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.178632"},{"key":"e_1_2_5_14_2","first-page":"171","article-title":"Collagen immobilization onto acrylic acid laser\u2010grafted silicone for using as artificial skin: In vitro","volume":"17","author":"Keshvari H","year":"2008","journal-title":"Iran Polym J"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.378"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/polb.10559"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.03.033"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/app.26216"},{"key":"e_1_2_5_19_2","first-page":"91","article-title":"Optimization of acrylic acid grafting onto POSS\u2010PCU nanocomposite using response surface methodology","volume":"20","author":"Solouk A","year":"2011","journal-title":"Iran Polym J"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(95)00316-9"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.01.003"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aorl.2008.01.005"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0460"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2009.0476"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.12.013"},{"key":"e_1_2_5_26_2","first-page":"255","article-title":"Comparison between tympanoplasties with cartilage\u2010perichondrium composite graft and temporal fascia graft in terms of hearing levels and healing","volume":"16","author":"Sapci T","year":"2006","journal-title":"Kulak Burun Bogaz Ihtis Derg"},{"key":"e_1_2_5_27_2","first-page":"585","article-title":"Underlay myringoplasty: Comparison of human amniotic membrane to temporalis fascia graft","volume":"60","author":"Harvinder S","year":"2005","journal-title":"Med J Malaysia"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otoeng.2010.12.003"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200104000-00025"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885328209104289"},{"key":"e_1_2_5_31_2","first-page":"6","article-title":"The study of collagen immobilization on a novel nanocomposite to enhance cell adhesion and growth","volume":"15","author":"Solouk A","year":"2011","journal-title":"Iran Biomed J"},{"key":"e_1_2_5_32_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1017\/S0022215106000697","article-title":"Myringoplasty","volume":"12","author":"Aggarwal R","year":"2006","journal-title":"J Laryngol Otol"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.02.012"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32119"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.33293","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.33293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T19:37:49Z","timestamp":1696793869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.33293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,12]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/jbm.a.33293"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.33293","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,12]]}}}