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The co\u2010oligomers assessed ranged in molecular weight (MW) from 1335 to 5208 Da and hydrophilic\u2013lipophilic balance (HLB) from 5.9 to 16.6 by varying the number of both PDMS and PEG units. In general, it was found that co\u2010oligomers of low MW or intermediate hydrophilicity significantly reduced fibroblast proliferation. A linear relationship between down\u2010regulation of fibroblast proliferation, and the ratio HLB\/MW was observed at concentrations of 0.1 and 1.0 wt % of the oligomers. This enabled the structures with highest efficiency to be determined. These results suggest the possible use of the PEG\u2013PDMS\u2013PEG block co\u2010oligomers as an alternative to silicone gels for hypertrophic scar remediation. \u00a9 2012 Wiley Periodicals, Inc. 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