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Hydrogels were also fabricated in the presence of \u03b1\u2010tocopherol to assess the release mechanism of a lipophilic drug from a highly\u2010hydrophilic CHT\/GEL hydrogel network. Alterations in the physico\u2010chemical properties of hydrogels were characterized by differential scanning calorimetry (DSC) and fourier transform infrared spectroscopy (FTIR), and their biostability was studied within a simulated body\u2010fluid solution (PBS of pH 7.4) at 37\u00b0C for 24 h by evaluating the degree of swelling, followed by topography and morphology characterization using scanning electron microscopy (SEM). The analysis confirmed the formation of a modulated hydrogels porosity using different freezing temperatures prior to lyophilization. The <jats:italic>in vitro<\/jats:italic> degradation behaviors of the hydrogels were investigated for up to 5 weeks using collagenase, lysozyme, and <jats:italic>N<\/jats:italic>\u2010acetyl\u2010\u03b2\u2010<jats:sc>D<\/jats:sc>\u2010glucosaminidase by monitoring the weight\u2010losses of hydrogels and their degradation products, being identified by UV\u2010Vis spectroscopy and high\u2010performance liquid chromatography (HPLC) as well as the pH monitoring of degraded solutions. It was observed that an inner morphological hydrogel structure influences their swelling and degradation behavior, which is additionally reduced by in\u2010gel\u2010embedded \u03b1\u2010tocopherol because of hydrophobic interactions with their constituents, and hindering the effect on collagenase activity. \u00a9 2012 Wiley Periodicals, Inc. 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