{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T21:31:54Z","timestamp":1772227914681,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T00:00:00Z","timestamp":1356134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Biodegradable composite matrices comprising poly\u2010(<jats:sc>L<\/jats:sc>\u2010lactic acid) (PLLA) and citric acid\u2010crosslinked alkali\u2010treated gelatin (AlGelatin) with endothelialization, antithrombogenic, and drug release properties were prepared. The characterization of composite matrices with various mixing ratios was performed by evaluating their swelling ratio, endothelial cell culture, antithrombogenic tests, and drug release behavior. Tamibarotene (Am80), which specifically inhibits smooth muscle cell proliferation, was employed as the drug. The swelling ratio of composite matrices decreased as the PLLA content decreased. The number of endothelial cells cultured on the surfaces of composite matrices was maximal at the PLLA\/AlGelatin\u2010TSC ratio of 80\/20. Antithrombogenic tests revealed that the levels of platelets and fibrin network formation decreased as the AlGelatin\u2010TSC content increased. The Am80 release test indicated that the release rate decreased as PLLA content increased. Using the resulting composite matrix, Am80\u2010eluting stents possessing a smooth surface and a coating thickness of \u223c15 \u03bcm were successfully obtained. Am80 was continuously released from the resulting stent at \u223c40%, up to 28 days without burst release. Therefore, Am80\u2010eluting stent with its antithrombogenic and endothelialization properties has great potential for clinical use. \u00a9 2012 Wiley Periodicals, Inc. 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