{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T08:02:35Z","timestamp":1784361755500,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T00:00:00Z","timestamp":1354665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>This study reports on the in vitro<\/jats:italic> and in vivo<\/jats:italic> behavior of \u03b1\u2010tricalcium phosphate (\u03b1TCP) and also \u03b1TCP doped with either 1.5 or 3.0 wt % of dicalcium silicate (C2<\/jats:sub>S). The ceramics were successfully prepared by powder metallurgy method combined with homogenization and heat treatment procedures. All materials were composed of a single\u2010phase, \u03b1TCP in the case of a pure material, or solid solution of C2<\/jats:sub>S in \u03b1TCP for the doped \u03b1TCP, which were stable at room temperature. The ceramics were tested for bioactivity in simulated body fluid, cell culture medium containing adult mesenchymal stem cells of human origin, and in animals. Analytical scanning electron microscopy combined with chemical elemental analysis was used and Fourier transform infrared and conventional histology methods. The in vivo<\/jats:italic> behavior of the ceramics matched the in vitro<\/jats:italic> results, independently of the C2<\/jats:sub>S content in \u03b1TCP. Carbonated hydroxyapatite (CHA) layer was formed on the surface and within the inner parts of the specimens in all cases. A fully mineralized new bone growing in direct contact with the implants was found under the in vivo<\/jats:italic> conditions. The bioactivity and biocompatibility of the implants increased with the C2<\/jats:sub>S content in \u03b1TCP. The C2<\/jats:sub>S doped ceramics also favoured a phase transformation of \u03b1TCP into CHA, important for full implant integration during the natural bone healing processes. \u03b1TCP ceramic doped with 3.0 wt % C2<\/jats:sub>S showed the best bioactive in vitro<\/jats:italic> and in vivo<\/jats:italic> properties of all the compositions and hence could be of interest in specific applications for bone restorative purposes. \u00a9 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.<\/jats:p>","DOI":"10.1002\/jbm.a.34495","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T22:35:57Z","timestamp":1354746957000},"page":"1943-1954","source":"Crossref","is-referenced-by-count":36,"title":["Retracted:<\/i> \u03b1TCP ceramic doped with dicalcium silicate for bone regeneration applications prepared by powder metallurgy method: In vitro<\/i> and in vivo<\/i> studies"],"prefix":"10.1002","volume":"101A","author":[{"given":"Pablo","family":"Velasquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia B.","family":"Luklinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Meseguer\u2010Olmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose E.","family":"Mate\u2010Sanchez de Val","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael A.","family":"Delgado\u2010Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Calvo\u2010Guirado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma. P.","family":"Ramirez\u2010Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piedad N.","family":"de Aza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,5]]},"updated-by":[{"DOI":"10.1002\/jbm.a.37098","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"record-id":"24519"},{"DOI":"10.1002\/jbm.a.37098","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000}}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.34495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.34495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.34495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T22:52:38Z","timestamp":1693867958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.34495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,5]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/jbm.a.34495"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.34495","archive":["Portico"],"relation":{"retraction":[{"id-type":"doi","id":"10.1002\/jbm.a.37098","asserted-by":"object"}]},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,5]]}}}