{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T17:54:50Z","timestamp":1765994090681},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T00:00:00Z","timestamp":1355356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Beta\u2010tricalcium phosphate (\u03b2\u2010TCP), one of the most widely used bioresorbable materials for bone therapy, can be doped with magnesium ions, generating \u03b2\u2010TCMP. The objectives of this work were to evaluate, on a murine dental alveolus grafting model, the biocompatibility of \u03b2\u2010TCP and \u03b2\u2010TMCP granules by histomorphometric analysis, as well as the impact on plasmatic levels of receptor activator of nuclear factor \u03baB ligand (RANK\u2010L), osteoprotegerin (OPG), osteocalcin, osteopontin, and parathormone (PTH) during bone repair, using Luminex multiplexing technology. After grafting for 42 days, \u03b2\u2010TCP grafted group presented higher bioresorption and induced more newly formed bone than \u03b2\u2010TCMP (<jats:italic>p<\/jats:italic>&lt; 0.05). \u03b2\u2010TCP grafting also induced higher plasmatic levels of RANK\u2010L, compared to \u03b2\u2010TCMP and control (blood clot) groups at 21st day (<jats:italic>p<\/jats:italic>&lt; 0.05). PTH, which remained at low levels in control group, presented a time\u2010dependent increase in grafted groups, attaining significantly higher levels with \u03b2\u2010TCP by the 42nd day (<jats:italic>p<\/jats:italic>&lt; 0.05). RANK\u2010L\/OPG ratio increased on \u03b2\u2010TCP group and attained a peak on the 21st day. In conclusion, \u03b2\u2010TCP granules were more bioresorbable and osteogenic than \u03b2\u2010TCMP granules, and the resorption of both materials might have been affected by osteoclastogenesis modulated by changes in the plasmatic levels of PTH and RANK\u2010L. \u00a9 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.<\/jats:p>","DOI":"10.1002\/jbm.a.34502","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T13:32:14Z","timestamp":1355405534000},"page":"1986-1993","source":"Crossref","is-referenced-by-count":13,"title":["Magnesium incorporation into \u03b2\u2010TCP reduced its<i>in vivo<\/i>resorption by decreasing parathormone production"],"prefix":"10.1002","volume":"101A","author":[{"given":"Debora H.","family":"Yassuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neusa F. 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