{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:11:33Z","timestamp":1771265493417,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T00:00:00Z","timestamp":1361318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>This study proposes a biodegradable nerve conduit comprising 1\u2010ethyl\u20103\u2010(3\u2010dimethylaminopropyl) carbodiimide (EDC) cross\u2010linked gelatin annexed with \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP) ceramic particles (EDC\u2010gelatin\u2010TCP, EGT). For this study, the EGT\u2010implant site in rats was irradiated using 660\u2010nm GaAlAsP laser diodes (50 mW) for trigger point therapy to investigate the use of low\u2010level laser (LLL) stimulation in the regeneration of a 15\u2010mm transected sciatic nerve. Animals were divided into three groups: a control group undergoing autologous nerve graft (autograft); a sham\u2010irradiated group (EGT), and an experimental group undergoing laser stimulation (EGT\/LS). Two trigger points on the surgical incision along the sciatic nerve were irradiated transcutaneously for 2 min daily for 10 consecutive days. Twelve weeks after implantation, walking track analysis showed a significantly higher sciatic functional index (SFI; <jats:italic>p<\/jats:italic> &lt; 0.05) and improved toe spreading development in the autograft and EGT\/LS groups, compared to the EGT group. In the electrophysiological measurement, the mean recovery index (peak amplitude and area) of the compound muscle action potential curves in the autograft and EGT\/LS groups showed significantly improved functional recovery than in the EGT group (<jats:italic>p<\/jats:italic> &lt; 0.05). Compared with the EGT group, the autograft and EGT\/LS groups showed a reduction in muscular atrophy. Histomorphometric assessments showed that the EGT\/LS group had undergone more rapid nerve regeneration than the EGT group. Therefore, motor function, electrophysiological reaction, muscular reinnervation, and histomorphometric assessments demonstrate that LLL therapy can accelerate the repair of a 15\u2010mm transected peripheral nerve in rats after being bridged with the EGT nerve conduit. \u00a9 2013 Wiley Periodicals, Inc. 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