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To resolve these problems, we developed hyperdry AM (HD\u2010AM) using far\u2010infrared rays, depression of air, and microwaves and then sterilized by \u03b3\u2010ray irradiation. To elucidate the benefit of HD\u2010AM as biological materials, compare with the physical and histological properties of HD\u2010AM with a freeze\u2010dried AM (FD\u2010AM) as typical freeze\u2010dried methods, evaluate the safety of HD\u2010AM in vivo experiment used nude mice, and demonstrate the feasibility of HD\u2010AM transplant in pterygium. The water permeability and the sieving coefficient of HD\u2010AM were significantly lower than that of FD\u2010AM. HD\u2010AM has kept the morphological structure of epithelium and connective tissues. At 18 months after transplanted, single and multilayers of HD\u2010AM in the intraperitoneal cavity was degraded without any infiltrated cells. For clinical treatment, recurrence of pterygium and regrowth of the subconjunctival fibrosis were not observed during the 6\u2010month follow\u2010up periods after the surgery. It was proposed that HD\u2010AM was a safe and effective new biological material for clinical use including treatment for recurrent pterygium. \u00a9 2013 Wiley Periodicals, Inc. 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