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This work sought to evaluate the biokinetics of different sized titanium dioxide particles (TiO<jats:sub>2<\/jats:sub>) and their potential to cause cell damage. Wistar rats were intraperitoneally injected with 150 nm, 10 nm, or 5nm TiO<jats:sub>2<\/jats:sub> particles. The presence of TiO<jats:sub>2<\/jats:sub> particles was evaluated in histologic sections of the liver, lung, and kidney and in blood cells at 3 and 12 months. Ultrastructural analysis of liver and lung tissue was performed by TEM, deposit concentration in tissues was determined spectroscopically, and oxidative metabolism was assessed by determining oxidative membrane damage, generation of superoxide anion (O<jats:sub>2<\/jats:sub><jats:sup>\u2010<\/jats:sup>), and enzymatic and non\u2010enzymatic antioxidants. TiO<jats:sub>2<\/jats:sub> particles were observed inside mononuclear blood cells and in organ parenchyma at 3 and 12 months. TiO<jats:sub>2<\/jats:sub> deposits were consistently larger in liver than in lung tissue. Alveolar macrophage O<jats:sub>2<\/jats:sub><jats:sup>\u2010<\/jats:sup> generation and average particle size correlated negatively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). NPs were more reactive and biopersistent in lung tissue than MPs. Antioxidant activity, particularly in the case of 5 nm particles, failed to compensate for membrane damage in liver cells; the damage was consistent with histological evidence of necrosis. \u00a9 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1439\u20131448, 2014.<\/jats:p>","DOI":"10.1002\/jbm.a.34822","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T20:34:33Z","timestamp":1371242073000},"page":"1439-1448","source":"Crossref","is-referenced-by-count":42,"title":["Impact through time of different sized titanium dioxide particles on biochemical and histopathological parameters"],"prefix":"10.1002","volume":"102","author":[{"given":"Marcos E.","family":"Bruno","sequence":"first","affiliation":[{"name":"Department of Oral Pathology School of Dentistry University of Buenos Aires Buenos Aires Argentina"},{"name":"School of Science and Technology National University of San Martin Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah R.","family":"Tasat","sequence":"additional","affiliation":[{"name":"School of Science and Technology National University of San Martin Buenos Aires Argentina"},{"name":"Department of Histology and Embryology School of Dentistry University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Paparella","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Evelson","sequence":"additional","affiliation":[{"name":"National Research Council (CONICET) Buenos Aires Argentina"},{"name":"General and Inorganic Chemistry Division School of Pharmacy and Biochemistry University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal Jim\u00e9nez","family":"Rebagliati","sequence":"additional","affiliation":[{"name":"Chemical Activity Unit National Atomic Energy Commission. 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