{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:43:16Z","timestamp":1790775796966,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T00:00:00Z","timestamp":1378080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of hydration on the biomechanical properties of fibrin and fibrin\u2010agarose (FA) tissue\u2010like hydrogels is reported. Native hydrogels with approximately 99.5% of water content and hydrogels with water content reduced until 90% and 80% by means of plastic compression (nanostructuration) were generated. The biomechanical properties of the hydrogels were investigated by tensile, compressive, and shear tests. Experimental results indicate that nanostructuration enhances the biomechanical properties of the hydrogels. This improvement is due to the partial draining of the water that fills the porous network of fibers that the plastic compression generates, which produces a denser material, as confirmed by scanning electron microscopy. Results also indicate that the characteristic compressive and shear parameters increase with agarose concentration, very likely due to the high water holding capacity of agarose, which reduces the compressibility and gives consistency to the hydrogels. However, results of tensile tests indicate a weakening of the hydrogels as agarose concentration increases, which evidences the anisotropic nature of these biomaterials. Interestingly, we found that by adjusting the water and agarose contents it is possible to tune the biomechanical properties of FA hydrogels for a broad range, within which the properties of many native tissues fall. \u00a9 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2573\u20132582, 2014.<\/jats:p>","DOI":"10.1002\/jbm.a.34929","type":"journal-article","created":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T08:06:38Z","timestamp":1377072398000},"page":"2573-2582","source":"Crossref","is-referenced-by-count":76,"title":["Effect of the hydration on the biomechanical properties in a fibrin\u2010agarose tissue\u2010like model"],"prefix":"10.1002","volume":"102","author":[{"given":"Giuseppe","family":"Scionti","sequence":"first","affiliation":[{"name":"Department of Histology University of Granada Avenida de Madrid 11 18012 Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Moral","sequence":"additional","affiliation":[{"name":"Department of Applied Physics University of Granada Avenida Fuente Nueva 18071 Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Toledano","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Granada Colegio M\u00e1ximo 18071 Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Osorio","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Granada Colegio M\u00e1ximo 18071 Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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