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In this work, a salicylate\u2010based PAE is a carrier to encapsulate and deliver insulin. Polymer microspheres were formulated using a water\/oil\/water double\u2010emulsion solvent evaporation technique. The microspheres obtained had a smooth surface, high protein encapsulation efficiency, and relatively low emulsifier content. Insulin was released <jats:italic>in vitro<\/jats:italic> for 15 days, with no signs of aggregation or unfolding of the secondary structure. The released insulin also retained bioactivity <jats:italic>in vitro<\/jats:italic>. Concurrently, SA was released from the microspheres with polymer degradation and anti\u2010inflammatory activity was observed. Based upon these results, the formulated microspheres enable simultaneous delivery of insulin and SA, both retaining bioactivity following processing. \u00a9 2013 Wiley Periodicals, Inc. 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