{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:23:31Z","timestamp":1781216611613,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":577,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1002\/jbm.a.35101","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T03:19:01Z","timestamp":1391570341000},"page":"n\/a-n\/a","source":"Crossref","is-referenced-by-count":2,"title":["Poly(ethylene glycol)-containing hydrogels promote the release of primary granules from human blood-derived polymorphonuclear leukocytes"],"prefix":"10.1002","author":[{"given":"Hannah Caitlin","family":"Cohen","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Division; School of Pharmacy; University of Wisconsin-Madison; 777 Highland Avenue Madison Wisconsin 53705"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler Jacob","family":"Lieberthal","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering; University of Wisconsin-Madison; 1550 Engineering Drive Madison Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.John","family":"Kao","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Division; School of Pharmacy; University of Wisconsin-Madison; 777 Highland Avenue Madison Wisconsin 53705"},{"name":"Department of Biomedical Engineering; University of Wisconsin-Madison; 1550 Engineering Drive Madison Wisconsin 53706"},{"name":"Department of Surgery; School of Medicine and Public Health; University of Wisconsin-Madison; 600 Highland Avenue Madison Wisconsin 53792"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"10.1002\/jbm.a.35101-BIB0001|jbma35101-cit-0001","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0002|jbma35101-cit-0002","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00002480-198804000-00005","article-title":"Inflammatory response to implants","volume":"34","author":"Anderson","year":"1988","journal-title":"ASAIO J"},{"key":"10.1002\/jbm.a.35101-BIB0003|jbma35101-cit-0003","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1073\/pnas.93.13.6454","article-title":"Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells","volume":"93","author":"LeCabec","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/jbm.a.35101-BIB0004|jbma35101-cit-0004","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1600-0609.1993.tb00629.x","article-title":"Human neutrophil granules and secretory vesicles","volume":"51","author":"Borregaard","year":"1993","journal-title":"Eur J Haematol"},{"key":"10.1002\/jbm.a.35101-BIB0005|jbma35101-cit-0005","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1074\/mcp.M500143-MCP200","article-title":"Proteomic analysis of human neutrophil granules","volume":"4","author":"Lominadze","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"10.1002\/jbm.a.35101-BIB0006|jbma35101-cit-0006","article-title":"Proteomic analysis of plasma membrane and secretory vesicles from human neutrophils","volume":"5","author":"Jethwaney","year":"2007","journal-title":"Prot Sci"},{"key":"10.1002\/jbm.a.35101-BIB0007|jbma35101-cit-0007","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1182\/blood-2008-02-139634","article-title":"Neutrophil secretion products pave the way for inflammatory monocytes","volume":"112","author":"Soehnlein","year":"2008","journal-title":"Blood"},{"key":"10.1002\/jbm.a.35101-BIB0008|jbma35101-cit-0008","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1172\/JCI35740","article-title":"Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages","volume":"118","author":"Soehnlein","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1002\/jbm.a.35101-BIB0009|jbma35101-cit-0009","first-page":"257","article-title":"Human neutrophil alpha-defensin modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells","volume":"11","author":"Chaly","year":"2000","journal-title":"Eur Cytokine Netw"},{"key":"10.1002\/jbm.a.35101-BIB0010|jbma35101-cit-0010","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1172\/JCI114394","article-title":"Monocyte-chemotactic activity of defensins from human-neutrophils","volume":"84","author":"Territo","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1002\/jbm.a.35101-BIB0011|jbma35101-cit-0011","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0014-5793(96)00639-4","article-title":"Characterization of recombinant human HBP\/CAP37\/azurocidin, a pleiotropic mediator of inflammation-enhancing LPS-induced cytokine release from monocytes","volume":"390","author":"Rasmussen","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1002\/jbm.a.35101-BIB0012|jbma35101-cit-0012","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.4049\/jimmunol.160.11.5530","article-title":"Heparin-binding protein (CAP37) is internalized in monocytes and increases LPS-induced monocyte activation","volume":"160","author":"Heinzelmann","year":"1998","journal-title":"J Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0013|jbma35101-cit-0013","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1084\/jem.186.5.739","article-title":"Identification of human neutrophil-derived cathepsin G and azurocidin\/CAP37 as chemoattractants for mononuclear cells and neutrophils","volume":"186","author":"Chertov","year":"1997","journal-title":"J Exp Med"},{"key":"10.1002\/jbm.a.35101-BIB0014|jbma35101-cit-0014","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.it.2009.06.006","article-title":"Neutrophil granule proteins tune monocytic cell function","volume":"30","author":"Soehnlein","year":"2009","journal-title":"Trends Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0015|jbma35101-cit-0015","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1182\/blood-2009-06-221630","article-title":"Mechanisms underlying neutrophil-mediated monocyte recruitment","volume":"114","author":"Soehnlein","year":"2009","journal-title":"Blood"},{"key":"10.1002\/jbm.a.35101-BIB0016|jbma35101-cit-0016","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1160\/TH08-11-0720","article-title":"Neutrophils launch monocyte extravasation by release of granule proteins","volume":"102","author":"Soehnlein","year":"2009","journal-title":"Thromb Haemostasis"},{"key":"10.1002\/jbm.a.35101-BIB0017|jbma35101-cit-0017","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00109-009-0508-6","article-title":"Direct and alternative antimicrobial mechanisms of neutrophil-derived granule proteins","volume":"87","author":"Soehnlein","year":"2009","journal-title":"J Mol Med (Heidelberg, Ger.)"},{"key":"10.1002\/jbm.a.35101-BIB0018|jbma35101-cit-0018","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1189\/jlb.0808495","article-title":"Neutrophil-derived azurocidin alarms the immune system","volume":"85","author":"Soehnlein","year":"2009","journal-title":"J Leukocyte Biol"},{"key":"10.1002\/jbm.a.35101-BIB0019|jbma35101-cit-0019","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.ajpath.2013.02.022","article-title":"Biomaterials selectively modulate interactions between human blood-derived polymorphonuclear leukocytes and monocytes","volume":"182","author":"Cohen","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1002\/jbm.a.35101-BIB0020|jbma35101-cit-0020","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1164\/ajrccm\/150.6_Pt_2.S114","article-title":"The role of neutrophil elastase in chronic inflammation","volume":"150","author":"Doring","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/jbm.a.35101-BIB0021|jbma35101-cit-0021","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1002\/art.1780390919","article-title":"Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis","volume":"39","author":"Ahrens","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1002\/jbm.a.35101-BIB0022|jbma35101-cit-0022","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.4049\/jimmunol.146.11.3922","article-title":"Degradation of cartilage matrix proteoglycan by human neutrophils involves both elastase and cathepsin-G","volume":"146","author":"Janusz","year":"1991","journal-title":"J Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0023|jbma35101-cit-0023","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1016\/j.actbio.2012.03.049","article-title":"Thiol-ene-based biological\/synthetic hybrid biomatrix for 3-D living cell culture","volume":"8","author":"Xu","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1002\/jbm.a.35101-BIB0024|jbma35101-cit-0024","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biomaterials.2011.09.044","article-title":"Active leukocyte detachment and apoptosis\/necrosis on PEG hydrogels and the implication in the host inflammatory response","volume":"33","author":"Waldeck","year":"2012","journal-title":"Biomaterials"},{"key":"10.1002\/jbm.a.35101-BIB0025|jbma35101-cit-0025","first-page":"50","article-title":"Matrix metalloproteinase-9 release from human leukocytes","volume":"13","author":"Takafuji","year":"2002","journal-title":"J Invest Allergol Clin Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0026|jbma35101-cit-0026","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-4889(02)00243-4","article-title":"Defensin-rich granules of human neutrophils: characterization of secretory properties","volume":"1591","author":"Faurschou","year":"2002","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1002\/jbm.a.35101-BIB0027|jbma35101-cit-0027","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1359-0286(99)00018-2","article-title":"Surfaces that resist bioadhesion","volume":"4","author":"Kingshott","year":"1999","journal-title":"Curr Opin Solid State Mater Sci"},{"key":"10.1002\/jbm.a.35101-BIB0028|jbma35101-cit-0028","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1163\/092050610X508400","article-title":"Application of MS-based proteomics to study serum protein adsorption\/absorption and complement C3 activation on poly(ethylene glycol) hydrogels","volume":"22","author":"Wang","year":"2011","journal-title":"J Biomater Sci Polym Ed"},{"key":"10.1002\/jbm.a.35101-BIB0029|jbma35101-cit-0029","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/1097-4636(20000905)51:3<343::AID-JBM7>3.0.CO;2-D","article-title":"Polyethylene glycol-coated biocompatible surfaces","volume":"51","author":"Alcantar","year":"2000","journal-title":"J Biomed Mater Res"},{"key":"10.1002\/jbm.a.35101-BIB0030|jbma35101-cit-0030","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0079-6700(95)00011-4","article-title":"Blood compatibility of polyethylene oxide surfaces","volume":"20","author":"Lee","year":"1995","journal-title":"Prog Polym Sci"},{"key":"10.1002\/jbm.a.35101-BIB0031|jbma35101-cit-0031","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/jbm.a.32595","article-title":"Characterization of the in vitro macrophage response and in vivo host response to poly(ethylene glycol)-based hydrogels","volume":"93A","author":"Lynn","year":"2010","journal-title":"J Biomed Mater Res Part A"},{"key":"10.1002\/jbm.a.35101-BIB0032|jbma35101-cit-0032","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/jbm.a.31270","article-title":"Monocyte activation in response to polyethylene glycol hydrogels grafted with RGD and PHSRN separated by interpositional spacers of various lengths","volume":"83A","author":"Schmidt","year":"2007","journal-title":"J Biomed Mater Res Part A"},{"key":"10.1002\/jbm.a.35101-BIB0033|jbma35101-cit-0033","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/0014-4827(91)90402-G","article-title":"Calcium signaling capacity of the CD11b\/CD18 integrin on human neutrophils","volume":"195","author":"Ngsikorski","year":"1991","journal-title":"Exp Cell Res"},{"key":"10.1002\/jbm.a.35101-BIB0034|jbma35101-cit-0034","doi-asserted-by":"crossref","first-page":"9472","DOI":"10.1073\/pnas.87.23.9472","article-title":"Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b\/CD18-integrin-triggered oscillations of cytosolic free Ca2+","volume":"87","author":"Richter","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/jbm.a.35101-BIB0035|jbma35101-cit-0035","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1074-7613(02)00303-5","article-title":"Syk is required for integrin signaling in neutrophils","volume":"16","author":"Mocsai","year":"2002","journal-title":"Immunity"},{"key":"10.1002\/jbm.a.35101-BIB0036|jbma35101-cit-0036","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.4049\/jimmunol.1002093","article-title":"Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection","volume":"186","author":"Kamen","year":"2011","journal-title":"J Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0037|jbma35101-cit-0037","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.4049\/jimmunol.162.2.1120","article-title":"Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck","volume":"162","author":"Mocsai","year":"1999","journal-title":"J Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0038|jbma35101-cit-0038","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1046\/j.1365-3083.2002.01041.x","article-title":"Degranulation of primary and secondary granules in adherent human neutrophils","volume":"55","author":"Xu","year":"2002","journal-title":"Scand J Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0039|jbma35101-cit-0039","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1182\/blood-2003-07-2624","article-title":"Rac2 is critical for neutrophil primary granule exocytosis","volume":"104","author":"Abdel-Latif","year":"2004","journal-title":"Blood"},{"key":"10.1002\/jbm.a.35101-BIB0040|jbma35101-cit-0040","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1189\/jlb.0605353","article-title":"Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: novel pathways for tertiary granule release","volume":"79","author":"Chakrabarti","year":"2006","journal-title":"J Leukocyte Biol"},{"key":"10.1002\/jbm.a.35101-BIB0041|jbma35101-cit-0041","doi-asserted-by":"crossref","first-page":"C1354","DOI":"10.1152\/ajpcell.00239.2008","article-title":"Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling","volume":"295","author":"Mitchell","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1002\/jbm.a.35101-BIB0042|jbma35101-cit-0042","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1073\/pnas.080074897","article-title":"Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation","volume":"97","author":"Ambruso","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/jbm.a.35101-BIB0043|jbma35101-cit-0043","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1139\/y04-123","article-title":"Neutrophil primary granule release and maximal superoxide generation depend on Rac2 in a common signalling pathway","volume":"83","author":"Abdel-Latif","year":"2005","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1002\/jbm.a.35101-BIB0044|jbma35101-cit-0044","doi-asserted-by":"crossref","first-page":"735","DOI":"10.4049\/jimmunol.146.2.735","article-title":"Signal transduction events and Fc gamma R engagement in human neutrophils stimulated with immune complexes","volume":"146","author":"Walker","year":"1991","journal-title":"J Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0045|jbma35101-cit-0045","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.4049\/jimmunol.173.3.2068","article-title":"Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: Full activation requires both integrin and nonintegrin signals","volume":"173","author":"Jakus","year":"2004","journal-title":"J Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0046|jbma35101-cit-0046","doi-asserted-by":"crossref","first-page":"C1264","DOI":"10.1152\/ajpcell.00177.2004","article-title":"Primary granule release from human neutrophils is potentiated by soluble fibrinogen through a mechanism depending on multiple intracellular signaling pathways","volume":"287","author":"Tuluc","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1002\/jbm.a.35101-BIB0047|jbma35101-cit-0047","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1182\/blood.V92.12.4819","article-title":"Adhesion-dependent release of elastase from human neutrophils in a novel, flow-based model: Specificity of different chemotactic agents","volume":"92","author":"Rainger","year":"1998","journal-title":"Blood"},{"key":"10.1002\/jbm.a.35101-BIB0048|jbma35101-cit-0048","first-page":"257","article-title":"Human neutrophil alpha-defensin modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells","volume":"11","author":"Chaly","year":"2000","journal-title":"Eur Cytokine Netw"},{"key":"10.1002\/jbm.a.35101-BIB0049|jbma35101-cit-0049","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1165\/ajrcmb.12.3.7873202","article-title":"Human neutrophil defensing and serpins form complexes and inactivate each other","volume":"12","author":"Panyutich","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1002\/jbm.a.35101-BIB0050|jbma35101-cit-0050","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1681\/ASN.V125932","article-title":"Proteinase 3 enhances endothelial monocyte chemoattractant protein-1 production and induces increased adhesion of neutrophils to endothelial cells by upregulating intercellular cell adhesion molecule-1","volume":"12","author":"Taekema-Roelvink","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1002\/jbm.a.35101-BIB0051|jbma35101-cit-0051","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0026-2862(03)00010-4","article-title":"CAP37, a neutrophil-derived inflammatory mediator, augments leukocyte adhesion to endothelial monolayers","volume":"66","author":"Lee","year":"2003","journal-title":"Microvasc Res"},{"key":"10.1002\/jbm.a.35101-BIB0052|jbma35101-cit-0052","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/ni1407","article-title":"Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs","volume":"7","author":"Mocsai","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1002\/jbm.a.35101-BIB0053|jbma35101-cit-0053","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1160\/TH07-02-0156","article-title":"Neutrophil activation via beta integrins (CD11\/CD18): Molecular mechanisms and clinical implications","volume":"98","author":"Schymeinsky","year":"2007","journal-title":"Thromb Haemostasis"},{"key":"10.1002\/jbm.a.35101-BIB0054|jbma35101-cit-0054","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a002352","article-title":"Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: Signaling cross talk","volume":"3","author":"Lowell","year":"2011","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"10.1002\/jbm.a.35101-BIB0055|jbma35101-cit-0055","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","article-title":"Neutrophil function: From mechanisms to disease","volume":"30","author":"Amulic","year":"2012","journal-title":"Annu Rev Immunol"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.35101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jbm.a.35101\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T23:35:58Z","timestamp":1716507358000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.35101"}},"subtitle":["Peg-Containing Hydrogels Activate Pmn<scp>s<\/scp>to Release Primary Granules"],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":55,"URL":"https:\/\/doi.org\/10.1002\/jbm.a.35101","relation":{},"ISSN":["1549-3296"],"issn-type":[{"value":"1549-3296","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}