{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:29:50Z","timestamp":1761676190176},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T00:00:00Z","timestamp":1408492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["EB008785"],"award-info":[{"award-number":["EB008785"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although a number of tissue adhesives and sealants for surgical use are currently available, attaining a useful balance in high strength, high compliance, and low swelling has proven difficult. Recent studies have demonstrated that a four\u2010arm poly(propylene oxide)\u2010poly(ethylene oxide) block copolymer, Tetronic, can be chemically modified to form a hydrogel tissue adhesive (Cho et al., Acta Biomater 2012;8:2223\u20132232; Barrett et al., Adv Health Mater 2012;1\u201311; Balakrishnan, Evaluating mechanical performance of hydrogel\u2010based adhesives for soft tissue applications. Clemson University, All Theses, Paper 1574: Tiger Prints; 2013). Building on the success of these studies, this study explored bifunctionalization of Tetronic with acrylates for chemical crosslinking of the hydrogel and <jats:italic>N<\/jats:italic>\u2010hydroxysuccinimide (NHS) for reaction with tissue amines. The adhesive bond strengths of various uni and bifunctional Tetronic blends (T1107 ACR: T1107 ACR\/NHS) determined by lap shear testing ranged between 8 and 74 kPa, with the 75:25 (T1107 ACR: T1107 ACR\/NHS) blend displaying the highest value. These results indicated that addition of NHS led to improvement of tissue bond strength over acrylation alone. Furthermore, <jats:italic>ex vivo<\/jats:italic> pressure tests using the rat bladder demonstrated that the bifunctional Tetronic adhesive exhibited high compliance and maintained pressures under hundreds of filling and emptying cycles. Together, the results of this study provided evidence that the bifunctional Tetronic adhesive with a proper blend ratio may be used to achieve an accurate balance in bulk and tissue bond strengths, as well as the compliance and durability for soft tissue such as the bladder. \u00a9 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 861\u2013868, 2015.<\/jats:p>","DOI":"10.1002\/jbm.a.35310","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T10:02:51Z","timestamp":1407751371000},"page":"861-868","source":"Crossref","is-referenced-by-count":14,"title":["Mechanical characterization of a bifunctional Tetronic hydrogel adhesive for soft tissues"],"prefix":"10.1002","volume":"103","author":[{"given":"Lindsey","family":"Sanders","sequence":"first","affiliation":[{"name":"Department of Bioengineering Clemson University Clemson South Carolina 29634"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Stone","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Clemson University Anderson South Carolina 29634"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Clemson University Clemson South Carolina 29634"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thompson","family":"Mefford","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Clemson University Anderson South Carolina 29634"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Nagatomi","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Clemson University Clemson South Carolina 29634"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.11.034"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64823-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01423-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00742-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201200332"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000461980","article-title":"Fibrin sealant: Scientific reationale, production methods, properties, and current clinical use","volume":"72","author":"Radosevich M","year":"1997","journal-title":"Vox Sang"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)01075-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/110241599750007522"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.02.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01703.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-88-470-1857-0","volume-title":"Thoraco\u2010abdominal aorta: Surgical and anesthetic management","author":"Chiesa R","year":"2011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04020.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540430071037"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(94)90199-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2001.tb00517.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000164384.05351.59"},{"key":"e_1_2_6_18_1","first-page":"302","article-title":"Hydrogel\u2010induced cervicomedullary compression after posterior fossa decompression for Chiari malformation","volume":"106","author":"Blackburn SL","year":"2007","journal-title":"J Neurosurg"},{"key":"e_1_2_6_19_1","unstructured":"Package Insert. 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