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Baseline \u03bcCT scans were conducted 7 days preimplantation of 2 \u00d7 10<jats:sup>8<\/jats:sup> PE particles\/mL over the calvariae (day 0). PAR at 1 mg\/kg\/day was subcutaneously injected on days 0, 4, 7, and 10. At day 14, BV and surface resorption was analyzed with \u03bcCT. Calvarial tissue was processed for histomorphometric osteocyte evaluation. Serum was analyzed for type\u20101 carboxy\u2010terminal collagen crosslinks (CTX\u20101) and osteoclast associated receptor (OSCAR) levels by ELISA. PE significantly decreased BV (<jats:italic>p =<\/jats:italic> 0.0368), increased surface bone resorption area (<jats:italic>p =<\/jats:italic> 0.0022), and increased the percentage of empty lacunae (<jats:italic>p =<\/jats:italic> 0.0043). Interestingly, PAR significantly reduced the resorption surface area (<jats:italic>p =<\/jats:italic> 0.0022) and the percentage of empty osteocyte lacunae (<jats:italic>p =<\/jats:italic> 0.0087) in the PE\u2010calvariae, but it did not affect BV, serum CTX\u20101 or OSCAR levels. The ability of PAR to inhibit PE\u2010induced surface bone erosion may better reflect the <jats:italic>in vivo<\/jats:italic> situation, where bone resorption occurs on the surface at the bone\u2010implant interface and may also be related to the role of osteocytes in this pathology. \u00a9 2015 Wiley Periodicals, Inc. 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