{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:41:23Z","timestamp":1791304883117,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["2R01 AR055650 and 1R01AR063717"],"award-info":[{"award-number":["2R01 AR055650 and 1R01AR063717"]}]},{"name":"Ellenburg Chair in Surgery in Stanford University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Wear particles induce periprosthetic inflammation and osteolysis through activation of nuclear factor kappa B (NF\u2010\u03baB), which up\u2010regulates the downstream target gene expression for proinflammatory cytokines in macrophages. It was hypothesized that direct suppression of NF\u2010\u03baB activity in the early phases of this disorder could be a therapeutic strategy for preventing the inflammatory response to wear particles, potentially mitigating osteolysis. NF\u2010\u03baB activity can be suppressed via competitive binding with double stranded NF\u2010\u03baB decoy oligodeoxynucleotides (ODNs) that blocks this transcription factor from binding to the promoter regions of targeted genes. In this murine calvarial study, clinically relevant polyethylene particles (PEs) with\/without ODN were subcutaneously injected over the calvarial bone. In the presence of PE particles, macrophages migrated to the inflammatory site and induced tumor necrosis factor alpha (TNF\u2010\u03b1) and receptor activator of nuclear factor kappa B ligand (RANKL) expression, resulting in an increase in the number of osteoclasts. Local injections of ODN mitigated the expression of TNF\u2010\u03b1, RANKL, and induced the expression of two anti\u2010inflammatory, antiresorptive cytokines: interleukin\u20101 receptor antagonist and osteoprotegerin. Local intervention with NF\u2010\u03baB decoy ODN in early cases of particle\u2010induced inflammation in which the prosthesis is still salvageable may potentially preserve periprosthetic bone stock. \u00a9 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3872\u20133878, 2015.<\/jats:p>","DOI":"10.1002\/jbm.a.35532","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T23:13:50Z","timestamp":1435619630000},"page":"3872-3878","source":"Crossref","is-referenced-by-count":27,"title":["NF\u2010\u03baB decoy oligodeoxynucleotide inhibits wear particle\u2010induced inflammation in a murine calvarial model"],"prefix":"10.1002","volume":"103","author":[{"given":"Taishi","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Pajarinen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010hua","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunobu","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Loi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Egashira","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research Development and Translational Medicine Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart B.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University Stanford California"},{"name":"Department of Bioengineering Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.06.035"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.09.034"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198803243181205"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523394"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-011-0366-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2313-x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(03)00156-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802612803531397"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.04.034"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2355"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.9.5766"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.10.027"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.07.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.11.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-1887-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.471268"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100180321"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0669-7_10"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21555"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.4.490"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00083-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0144"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.35532","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.35532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:57:37Z","timestamp":1696377457000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.35532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/jbm.a.35532"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.35532","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]}}}