{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:09:48Z","timestamp":1789726188662,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T00:00:00Z","timestamp":1447027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20 HL113451 and R01 AR062920"],"award-info":[{"award-number":["P20 HL113451 and R01 AR062920"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis is a progressive joint disease that results in degradation of cartilage in load\u2010bearing joints. Pain and inflammation in the joint are the hallmarks of this condition, which further exacerbate the cartilage destruction and health of the patient. It is hence imperative to treat the joint inflammation at the earliest. Interleukin 1 (IL\u20101) blockade by IL\u20101 receptor antagonist (IL\u20101Ra) has shown promise in the clinic but this therapy suffers from rapid clearance, high doses, and frequent intervention. Use of carrier particles that result in longer residence time has been proposed. Here we have synthesized a new class of nanoparticles presenting IL\u20101Ra on the surface and with tunable size from 300 to 700 nm. These IL\u20101Ra\u2010poly(2\u2010hydroxyethyl methacrylate)\u2010pyridine nanoparticles are cytocompatible and stable in serum\u2010containing solutions for several days. Our results further demonstrate that these nanoparticles are capable of blocking IL\u20101\u03b2 signaling in an NF\u2010\u03baB inducible reporter cell line. These engineered nanoparticles are promising for localized intra\u2010articular delivery in joint space to reduce inflammation in osteoarthritis and other inflammatory diseases. \u00a9 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 595\u2013599, 2016.<\/jats:p>","DOI":"10.1002\/jbm.a.35601","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T10:38:02Z","timestamp":1446028682000},"page":"595-599","source":"Crossref","is-referenced-by-count":30,"title":["Synthesis of self\u2010assembled IL\u20101Ra\u2010presenting nanoparticles for the treatment of osteoarthritis"],"prefix":"10.1002","volume":"104","author":[{"given":"Rachit","family":"Agarwal","sequence":"first","affiliation":[{"name":"Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta Georgia 30332"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago M.","family":"Volkmer","sequence":"additional","affiliation":[{"name":"Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta Georgia 30332"},{"name":"Materials Engineering Department Franciscan University Center Santa Maria RS 97010\u2010491 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of South Carolina  Columbia South Carolina 29208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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