{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:48:29Z","timestamp":1790002109942,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T00:00:00Z","timestamp":1447286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Areas of Advance Energy and Materials Science at Chalmers University of Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A recent approach to improve the osseointegration of implants is to utilize local drug administration. The presence of an osteoporosis drug may influence both bone quantity and quality at the bone\/implant interface. Despite this, the performance of bone\u2010anchoring implants is traditionally evaluated only by quantitative measurements. In the present study, the osteoporosis drug alendronate (ALN) was administrated from mesoporous titania thin films that were coated onto titanium implants. The effect that the drug had on biomineralization was explored both <jats:italic>in vitro<\/jats:italic> using simulated body fluid (SBF) and <jats:italic>in vivo<\/jats:italic> in a rat tibia model. The SBF study showed that the apatite formation was completely hindered at a high concentration of ALN (0.1 mg\/mL). However, when ALN was administrated from the mesoporous coating the surface became completely covered with apatite. <jats:italic>Ex vivo<\/jats:italic> characterization of the bone\/implant interface using Raman spectroscopy demonstrated that the presence of ALN enhanced the bone mineralization, and that the chemical signature of newly formed bone in the presence of ALN had a higher resemblance to the pre\u2010existing mature bone than to the bone formed without drug. Taken together, this study demonstrates the importance of evaluating the quality of the formed bone to better understand the performance of implants. \u00a9 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A 104A: 620\u2013629, 2016.<\/jats:p>","DOI":"10.1002\/jbm.a.35602","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T10:36:55Z","timestamp":1446028615000},"page":"620-629","source":"Crossref","is-referenced-by-count":14,"title":["The effect of alendronate on biomineralization at the bone\/implant interface"],"prefix":"10.1002","volume":"104","author":[{"given":"Johan","family":"Karlsson","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Engineering Chalmers University of Technology Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering Chalmers University of Technology Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda M.","family":"Fathali","sequence":"additional","affiliation":[{"name":"Department of 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