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Thus, this study evaluated the effects of BMP\u20102 and bFGF at specified dose ratio composited with n\u2010HA\/PU40, a porous scaffold material, for repairing femoral defect in rats. Four weeks after implantation of this composite system, tissue specimens were collected for histological, <jats:italic>immunohistochemical<\/jats:italic> examinations, and \u00b5\u2010CT scanning. The results showed that the group DUAL\/BMSCs with both the factors had better effect on repairing bone defects than the other four groups in terms of new bone formation and bone\u2010scaffold bonding, suggesting crosstalk between these growth factors during early bone regeneration. This work demonstrates that provided that there is effective contact between cells and active proteins in the defect area, the controlled release of bFGF and BMP\u20102 have positive synergistic effects on early bone formation in the defect area. \u00a9 2015 Wiley Periodicals, Inc. 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