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In this work, an antipathogenic tripolyacrylamide containing aliphatic quaternary phosphonium salt (QPS) was prepared. To confirm the broad\u2010spectrum antipathogenic activity of the as\u2010prepared polymer, the <jats:italic>in vitro<\/jats:italic> antibacterial performance was evaluated against <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>E. coli<\/jats:italic>) and <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:italic>S. aureus<\/jats:italic>) and viral inactivation was assessed against influenza virus and adenovirus as well. The polymers exhibited higher bactericidal activity against <jats:italic>S. aureus<\/jats:italic> than <jats:italic>E. coli<\/jats:italic> in terms of minimal inhibitory concentration (MIC), while possessing much lower MIC values compared with their corresponding compound. The morphological alterations in polymer treated <jats:italic>E. coli<\/jats:italic>, captured by atomic force microscopy, confirmed the membrane\u2010acting antibacterial mechanism of polymeric QPS. The plaque reduction assay performed on influenza virus and adenovirus demonstrated the as\u2010prepared tripolymer could efficiently inactivate both enveloped and non\u2010enveloped viruses, and the two different antiviral mechanisms were elucidated correspondingly. \u00a9 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 747\u2013757, 2016.<\/jats:p>","DOI":"10.1002\/jbm.a.35613","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T08:38:44Z","timestamp":1447490324000},"page":"747-757","source":"Crossref","is-referenced-by-count":27,"title":["Characterization and antipathogenic evaluation of a novel quaternary phosphonium tripolyacrylamide and elucidation of the inactivation mechanisms"],"prefix":"10.1002","volume":"104","author":[{"given":"Yan","family":"Xue","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Oil &amp; Gas Field Applied Chemistry Key Laboratory of Sichuan Province Southwest Petroleum University Chengdu 610500 People's Republic of China"},{"name":"Department of Chemical Engineering University of New Brunswick Fredericton New Brunswick E3B 5A3 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