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It could cause chronic pelvic pain, intestinal obstruction, and infertility. A hydrogel biomaterial, carbodiimide\u2010derivatized hyaluronic acid gelatin (cd\u2010HA gelatin), has been successfully used to reduce adhesion formation after flexor tendon grafting. This study investigated the efficacy of cd\u2010HA gelatin in preventing postsurgical peritoneal adhesions in a rat model. The surgical traumas were created on the underlying muscle of the abdominal wall and the serosal layer of the cecum. The wounds were covered with or without cd\u2010HA gelatin. Animals were euthanized at day 14 after surgery. Adhesion formation was assessed with adhesion degree and adhesion breaking strength. The healing of abdominal wall was evaluated with biomechanical testing and histological analysis. The adhesions occurred in all rats (<jats:italic>n<\/jats:italic>\u2009=\u200912) without cd\u2010HA gelatin treatment. The application of cd\u2010HA gelatin significantly reduced the adhesion rate from 100% to 58%. The decrease of adhesion breaking strength also manifested that cd\u2010HA gelatin could reduce postsurgical intra\u2010abdominal adhesion formation. Moreover, it was found that cd\u2010HA gelatin was a safe material and could promote tissue healing. The cd\u2010HA gelatin hydrogel could reduce the formation of intra\u2010abdominal adhesions without adversely effects on wound healing. \u00a9 2016 Wiley Periodicals, Inc. 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