{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:36:33Z","timestamp":1772138193204,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 103-2221-E-038-023"],"award-info":[{"award-number":["MOST 103-2221-E-038-023"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1002\/jbm.a.35729","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:39:59Z","timestamp":1459381199000},"page":"2071-2079","source":"Crossref","is-referenced-by-count":24,"title":["<scp>l<\/scp>-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes"],"prefix":"10.1002","volume":"104","author":[{"given":"Kai-Chiang","family":"Yang","sequence":"first","affiliation":[{"name":"School of Dental Technology; College of Oral Medicine, Taipei Medical University; Taipei 11031 Taiwan"},{"name":"Department of Organ Reconstruction; Institute for Frontier Medical Sciences, Kyoto University; Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Chin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics; National Taiwan University Hospital, College of Medicine, National Taiwan University; Taipei 10002 Taiwan"},{"name":"Department of Orthopedics; En Chu Kong Hospital; New Taipei City 23702 Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering; University of Sheffield; Sheffield S10 2TN United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichiro","family":"Sumi","sequence":"additional","affiliation":[{"name":"Department of Organ Reconstruction; Institute for Frontier Medical Sciences, Kyoto University; Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng-Le","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine; College of Health Care, China Medical University; Taichung 40402 Taiwan"},{"name":"Department of Orthopedics; An-Nan Hospital, China Medical University; Tainan 70965 Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,26]]},"reference":[{"key":"10.1002\/jbm.a.35729-BIB0001|jbma35729-cit-0002","first-page":"3","article-title":"Viscosupplementation: A new concept in the treatment of osteoarthritis","volume":"20","author":"Balazs","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1002\/jbm.a.35729-BIB0002|jbma35729-cit-0003","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1503\/cmaj.1041203","article-title":"Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis","volume":"172","author":"Arrich","year":"2005","journal-title":"CMAJ"},{"key":"10.1002\/jbm.a.35729-BIB0003|jbma35729-cit-0004","first-page":"33.e1","article-title":"Conflict of interest in the assessment of hyaluronic acid injections for osteoarthritis of the knee: An updated systematic review","volume":"2814","author":"Printz","year":"2013","journal-title":"J Arthroplasty"},{"key":"10.1002\/jbm.a.35729-BIB0004|jbma35729-cit-0005","first-page":"59","article-title":"Rheological properties of synovial fluids","volume":"44","author":"Fam","year":"2007","journal-title":"Biorheology"},{"key":"10.1002\/jbm.a.35729-BIB0005|jbma35729-cit-0006","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1302\/0301-620X.87B8.15083","article-title":"The effects of hyaluronic acid on articular chondrocytes","volume":"87","author":"Akmal","year":"2005","journal-title":"J Bone Joint Surg Br"},{"key":"10.1002\/jbm.a.35729-BIB0006|jbma35729-cit-0007","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/147323000603400110","article-title":"Comparison between high and low molecular weight hyaluronates in knee osteoarthritis patients: open-label, randomized, multicentre clinical trial","volume":"34","author":"Lee","year":"2006","journal-title":"J Int Med Res"},{"key":"10.1002\/jbm.a.35729-BIB0007|jbma35729-cit-0008","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.joca.2005.09.003","article-title":"A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee","volume":"14","author":"Kirchner","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0008|jbma35729-cit-0009","first-page":"917","article-title":"Evaluation of patients presenting with knee pain: Part II. Differential diagnosis","volume":"68","author":"Calmbach","year":"2003","journal-title":"Am Fam Phys"},{"key":"10.1002\/jbm.a.35729-BIB0009|jbma35729-cit-0010","first-page":"290","article-title":"Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: Effects on synovial inflammation, bone erosion, and cartilage destruction","volume":"5020","author":"Zwerina","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1002\/jbm.a.35729-BIB0010|jbma35729-cit-0011","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.joca.2009.09.008","article-title":"Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes","volume":"18","author":"Kim","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0011|jbma35729-cit-0012","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.joca.2005.04.002","article-title":"Oxygen and reactive oxygen species in cartilage degradation: friends or foes?","volume":"13","author":"Henrotin","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0012|jbma35729-cit-0013","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.joca.2005.08.009","article-title":"Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint","volume":"14","author":"Ostalowska","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0013|jbma35729-cit-0014","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1038\/sj.onc.1209936","article-title":"Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance","volume":"25","author":"Bubici","year":"2006","journal-title":"Oncogene"},{"key":"10.1002\/jbm.a.35729-BIB0014|jbma35729-cit-0015","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/rheumatology\/kel026","article-title":"Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-kappaB and p38. 26","volume":"45","author":"Hiramitsu","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"10.1002\/jbm.a.35729-BIB0015|jbma35729-cit-0016","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1053\/joca.1999.0292","article-title":"Tumor necrosis factor alpha can contribute to focal loss of cartilage in osteoarthritis","volume":"8","author":"Westacott","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0016|jbma35729-cit-0017","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.joca.2007.09.001","article-title":"Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury","volume":"16","author":"Regan","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0017|jbma35729-cit-0018","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0167-4889(91)90117-G","article-title":"Effects of glutathione depletion on the synthesis of proteoglycan and collagen in cultured chondrocytes","volume":"1093","author":"Habuchi","year":"1991","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/jbm.a.35729-BIB0018|jbma35729-cit-0019","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.joca.2005.08.009","article-title":"Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint","volume":"14","author":"Ostalowska","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0019|jbma35729-cit-0020","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jbspin.2007.02.002","article-title":"Reactive oxygen species and superoxide dismutases: Role in joint diseases","volume":"32","author":"Afonso","year":"2007","journal-title":"Joint Bone Spine"},{"key":"10.1002\/jbm.a.35729-BIB0020|jbma35729-cit-0021","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4049\/jimmunol.174.2.864","article-title":"Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines","volume":"174","author":"Ohata","year":"2005","journal-title":"J Immunol"},{"key":"10.1002\/jbm.a.35729-BIB0021|jbma35729-cit-0022","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1002\/jbm.a.35729-BIB0022|jbma35729-cit-0023","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1002\/art.11338","article-title":"Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels","volume":"48","author":"Carlo","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1002\/jbm.a.35729-BIB0023|jbma35729-cit-0024","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.joca.2006.02.006","article-title":"Biochemical effects of two different hyaluronic acid products in a co-culture model of osteoarthritis","volume":"14","author":"Greenberg","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0024|jbma35729-cit-0025","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/art.21523","article-title":"Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes","volume":"54","author":"Steenvoorden","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1002\/jbm.a.35729-BIB0025|jbma35729-cit-0026","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0736-0266(00)90024-X","article-title":"Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model","volume":"19","author":"Takahashi","year":"2001","journal-title":"J Orthop Res"},{"key":"10.1002\/jbm.a.35729-BIB0026|jbma35729-cit-0027","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2460\/ajvr.67.6.957","article-title":"Assessment of the catabolic effects of interleukin-1beta on proteoglycan metabolism in equine cartilage cocultured with synoviocytes","volume":"67","author":"Gregg","year":"2006","journal-title":"Am J Vet Res"},{"key":"10.1002\/jbm.a.35729-BIB0027|jbma35729-cit-0028","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.procbio.2009.02.008","article-title":"The dose dependent effects of betulin on porcine chondrocytes","volume":"44","author":"Lin","year":"2009","journal-title":"Process Biochem"},{"key":"10.1002\/jbm.a.35729-BIB0028|jbma35729-cit-0029","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.procbio.2015.06.014","article-title":"The effects of negative pressure treatment on the extracellular matrix gene expression and protein production of fibroblasts","volume":"50","author":"Chen","year":"2015","journal-title":"Process Biochem"},{"key":"10.1002\/jbm.a.35729-BIB0029|jbma35729-cit-0030","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jor.20988","article-title":"Influence of age-related degeneration on regenerative potential of human nucleus pulposus cells","volume":"28","author":"Yang","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1002\/jbm.a.35729-BIB0030|jbma35729-cit-0031","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00011-010-0165-9","article-title":"The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: Inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level","volume":"59","author":"Chen","year":"2010","journal-title":"Inflamm Res"},{"key":"10.1002\/jbm.a.35729-BIB0031|jbma35729-cit-0032","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.procbio.2015.12.010","article-title":"Glutamine regulates the expression of matrix proteins, pro-inflammatory cytokines and catabolic enzymes in IL-1\u03b2-stimulated human chondrocytes","volume":"51","author":"Yang","year":"2016","journal-title":"Process Biochem"},{"key":"10.1002\/jbm.a.35729-BIB0032|jbma35729-cit-0033","first-page":"763","article-title":"Interleukin-1beta and interleukin-6 disturb the antioxidant enzyme system in bovine chondrocytes: A possible explanation for oxidative stress generation","volume":"1649","author":"Mathy-Hartert","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0033|jbma35729-cit-0034","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.joca.2006.05.009","article-title":"High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis","volume":"50","author":"Wang","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0034|jbma35729-cit-0035","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bbrc.2013.02.043","article-title":"Mechanisms involved in suppression of ADAMTS4 expression in synoviocytes by high molecular weight hyaluronic acid","volume":"432","author":"Kataoka","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/jbm.a.35729-BIB0035|jbma35729-cit-0036","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1128\/CDLI.5.4.430-437.1998","article-title":"T cells and T-cell cytokine transcripts in the synovial membrane in patients with osteoarthritis","volume":"5","author":"Sakkas","year":"1998","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1002\/jbm.a.35729-BIB0036|jbma35729-cit-0037","first-page":"870","article-title":"Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage","volume":"26","author":"Moos","year":"1999","journal-title":"J Rheumatol"},{"issue":"Suppl A","key":"10.1002\/jbm.a.35729-BIB0037|jbma35729-cit-0038","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.joca.2003.10.002","article-title":"Pathophysiology of osteoarthritis","volume":"12","author":"Martel-Pelletier","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0038|jbma35729-cit-0039","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1023\/A:1026028303196","article-title":"Regulation of matrix metalloproteinases: An overview","volume":"253","author":"Chakraborti","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"10.1002\/jbm.a.35729-BIB0039|jbma35729-cit-0040","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.joca.2010.08.016","article-title":"Circulating levels of IL-6 and TNF-\u03b1 are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults","volume":"18","author":"Stannus","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0040|jbma35729-cit-0041","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/03009740701250785","article-title":"Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells","volume":"36","author":"Doss","year":"2007","journal-title":"Scand J Rheumatol"},{"key":"10.1002\/jbm.a.35729-BIB0041|jbma35729-cit-0042","first-page":"177","article-title":"Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice","volume":"151","author":"Loo","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1002\/jbm.a.35729-BIB0042|jbma35729-cit-0043","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.joca.2004.09.011","article-title":"Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging","volume":"13","author":"Hooge","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jbm.a.35729-BIB0043|jbma35729-cit-0044","doi-asserted-by":"crossref","first-page":"13625c","DOI":"10.1074\/jbc.273.22.13625","article-title":"Interleukin (IL)\u22126 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity","volume":"273","author":"Silacci","year":"1998","journal-title":"J Biol Chem"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.35729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.35729","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jbm.a.35729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T13:38:17Z","timestamp":1625492297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.35729"}},"subtitle":["Glutathione Enhances Antioxidant Capacity to Hyaluronon"],"short-title":[],"issued":{"date-parts":[[2016,4,26]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"URL":"https:\/\/doi.org\/10.1002\/jbm.a.35729","archive":["Portico"],"relation":{},"ISSN":["1549-3296"],"issn-type":[{"value":"1549-3296","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4,26]]}}}