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In this study, the effect of continuous IL\u20104 delivery or bioactive implant coating that constitutively releases a protein inhibitor of CCL2 signaling (7ND) on particle induced osteolysis were studied in the murine continuous femoral intramedullary particle infusion model. Polyethylene particles with or without IL\u20104 were infused into mouse distal femurs implanted with hollow titanium rods using subcutaneous infusion pumps. In another experimental group, particles were infused into the femur through a 7ND coated rod. After 4 weeks, fixation of the implant was assessed using a pullout test. The volume of trabecular bone and the geometry of the local cortical bone were assessed by \u00b5CT and the corresponding structural properties of the cortical bone determined by torsional testing. Continuous IL\u20104 delivery led to increased trabecular bone volume as well as enhanced local bone geometry and structural properties, while 7ND implant coating did not have effect on these parameters. The results suggest that local IL\u20104 treatment is a promising strategy to mitigate wear particle induced osteolysis. \u00a9 2016 Wiley Periodicals, Inc. 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