{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:30:54Z","timestamp":1791307854524,"version":"4.3.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T00:00:00Z","timestamp":1467676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tarbiat Modares University, Tehran"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Functionalization of gold nanoparticles (GNPs) is suitable for many applications such as biomedical imaging, clinical diagnosis, and targeted delivery by conjugating cell\u2010penetrating peptides (CPPs). Here, we investigated intracellular uptake of GNP conjugated to MCa<jats:sub>UF1\u20109(Ala)<\/jats:sub>, a CPP derived from maurocalcine (MCa) animal toxin, and compared it with TAT functionalized GNP. Peptide conjugated GNP was characterized using UV\u2010Visible spectroscopy, dynamic light scattering, zeta potential, and transmission electron microscopy. Uptake of MCa<jats:sub>UF1\u20109(Ala)<\/jats:sub> and TAT functionalized GNPs was evaluated in three cell lines, HeLa, MDA\u2010MB\u2010231, and A431, using dark field imaging and atomic absorption spectroscopy. According to peptide sequences and type of cells different cell penetrating activity was observed. Peptide functionalized GNP had little effect on cell viability and respect to net charge difference between peptide, showed interesting selectivity against three cell types. Peptide conjugated to GNPs displayed higher uptake than bare GNPs in the all cell lines except HeLa cell with lowest internalization. \u00a9 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2693\u20132700, 2016.<\/jats:p>","DOI":"10.1002\/jbm.a.35806","type":"journal-article","created":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:26:45Z","timestamp":1466468805000},"page":"2693-2700","source":"Crossref","is-referenced-by-count":26,"title":["Enhanced and selective permeability of gold nanoparticles functionalized with cell penetrating peptide derived from maurocalcine animal toxin"],"prefix":"10.1002","volume":"104","author":[{"given":"Sedigheh","family":"Khamehchian","sequence":"first","affiliation":[{"name":"Department of Nanobiotechnology Faculty of Biological Science, Tarbiat Modares University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nikkhah","sequence":"additional","affiliation":[{"name":"Department of Nanobiotechnology Faculty of Biological Science, Tarbiat Modares University Tehran 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