{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:56:33Z","timestamp":1790524593855,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T00:00:00Z","timestamp":1467590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The surface topography of a biomaterial plays a vital role in determining macrophage interactions and influencing immune response. In this study, we investigated the effect of smooth and microrough topographies of commonly used metallic biomaterials such as 316 L stainless steel (SS) and cobalt\u2010chromium (CoCr) alloys on macrophage interactions. The macrophage adhesion was greater on CoCr compared to SS, irrespective of their topographies. The macrophage activation and the secretion of most pro\u2010inflammatory cytokines (TNF\u2010\u03b1, IL\u20106, and IP\u201010) were greater on microrough surfaces than on smooth surfaces by day\u20101. However, by day\u20102, the macrophage activation on smooth surfaces was also significantly increased up to the same level as observed on the microrough surfaces, with more amount of cytokines secreted. The secretion of anti\u2010inflammatory cytokine (IL\u201010) was significantly increased from day\u20101 to day\u20102 on all the alloy surfaces with the effect most prominently observed on microrough surfaces. The production of nitric oxide by the macrophages did not show any major substrate\u2010dependent effect. The foreign body giant cells formed by macrophages were least observed on the microrough surfaces of CoCr. Thus, this study demonstrated that the nature of material (SS or CoCr) and their surface topographies (smooth or microrough) strongly influence the macrophage responses. \u00a9 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2658\u20132672, 2016.<\/jats:p>","DOI":"10.1002\/jbm.a.35808","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T20:26:51Z","timestamp":1466454411000},"page":"2658-2672","source":"Crossref","is-referenced-by-count":26,"title":["Macrophage responses to 316L stainless steel and cobalt chromium alloys with different surface topographies"],"prefix":"10.1002","volume":"104","author":[{"given":"Jordan A.","family":"Anderson","sequence":"first","affiliation":[{"name":"Biomedical Engineering Program the University of South Dakota 4800 N. Career Avenue Sioux Falls South Dakota 57107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujan","family":"Lamichhane","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Program the University of South Dakota 4800 N. Career Avenue Sioux Falls South Dakota 57107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopinath","family":"Mani","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Program the University of South Dakota 4800 N. Career Avenue Sioux Falls South Dakota 57107"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1833592"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.10.043"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1877610801002010040"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00009-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.4.1168"},{"key":"e_1_2_6_7_1","first-page":"139","article-title":"Metallic surface modification","volume":"3","author":"Scheerder I","year":"1998","journal-title":"Semin Interv Cardiol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.11.042"},{"key":"e_1_2_6_9_1","first-page":"173","article-title":"Microrough surface of metallic biomaterials: A literature review","volume":"6","author":"Wen X","year":"1996","journal-title":"Biomed Mater Eng"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v021a32"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30075"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.05.021"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2007.07.008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(99)70063-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfcoat.2006.07.064"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30066"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.01.055"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.034"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2015.01.019"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma8095269"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm200248h"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34562"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32893"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20400"},{"key":"e_1_2_6_26_1","first-page":"71","article-title":"Scanning electron microscopic analysis of defects in polymer coatings of three commercially available stents: Comparison of BiodivYsio, Taxus and Cypher stents","volume":"19","author":"Otsuka Y","year":"2007","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-014-1108-3"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820290112"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199603)30:3<305::AID-JBM5>3.0.CO;2-U"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/la501448h"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/la301636z"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6663-6669.2000"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.04.004"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.12.029"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9913255"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31221"},{"key":"e_1_2_6_37_1","first-page":"1487","article-title":"Interleukin\u20104 induces foreign body giant cells from human monocytes\/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells","volume":"147","author":"McNally AK","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.06.050"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-279"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.074"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10102-010-0044-9"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.02.025"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.323"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199807)41:7<1141::AID-ART2>3.0.CO;2-S"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.07.010"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.12.003"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130111.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.50.1.1"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31863"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00612"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2012.0006"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2008-1090"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.35808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.35808","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.35808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T17:52:04Z","timestamp":1694281924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.35808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,4]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/jbm.a.35808"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.35808","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,4]]}}}