{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:00:50Z","timestamp":1790845250112,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,21]],"date-time":"2016-08-21T00:00:00Z","timestamp":1471737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["26293341"],"award-info":[{"award-number":["26293341"]}]},{"name":"JSPS KAKENHI","award":["26460527"],"award-info":[{"award-number":["26460527"]}]},{"DOI":"10.13039\/100008732","name":"The Uehara Memorial Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kitasato University Research Grant for Young Researchers"},{"name":"Parents' Association of Kitasato University School of Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We developed a new scaffold material\u2014oriented collagen tubes (OCT)\u2014and evaluated the potential of OCTs combined with basic fibroblast growth factor (bFGF) to repair of a 15\u00a0mm sciatic nerve defect in rats. The treatment groups consisted of OCT with adsorbed bFGF (OCT\/bFGF group), OCT in phosphate\u2010buffered saline (PBS) (OCT\/PBS group), and a no\u2010treatment group (Defect group). Functional evaluation of nerve regeneration was performed using the CatWalk system, and histological analyses of the defect sites were also performed. In rats treated with either OCT\/bFGF or OCT\/PBS, the walking function parameter of max contact area returned to normal levels by 4 weeks after grafting, and the regeneration of myelinated fibers was detected after 8 weeks. However, more regenerated myelinated fibers were observed in the OCT\/bFGF group compared with the OCT\/PBS group at 4 weeks. In addition, the max contact area and swing speed in the OCT\/bFGF group were significantly recovered compared to the OCT\/PBS and Defect groups at 8 weeks. Although the combination of bFGF and OCT was superior to OCT alone for nerve regeneration and functional recovery, the present findings demonstrate that OCT alone or in combination with bFGF accelerates nerve repair in a large peripheral nerve defect in rats. \u00a9 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 8\u201314, 2017.<\/jats:p>","DOI":"10.1002\/jbm.a.35866","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T16:52:37Z","timestamp":1471366357000},"page":"8-14","source":"Crossref","is-referenced-by-count":49,"title":["Oriented collagen tubes combined with basic fibroblast growth factor promote peripheral nerve regeneration in a 15\u00a0mm sciatic nerve defect rat model"],"prefix":"10.1002","volume":"105","author":[{"given":"Hisako","family":"Fujimaki","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Kitasato University School of Medicine 1\u201015\u20101 Minami\u2010ku Kitasato Sagamihara Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kitasato University School of Medicine 1\u201015\u20101 Minami\u2010ku Kitasato Sagamihara Kanagawa 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