{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:04:58Z","timestamp":1790791498734,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Young Scientists","award":["24700458"],"award-info":[{"award-number":["24700458"]}]},{"name":"Grant-in-Aid from the Japan Society for the Promotion of Science","award":["12J05932"],"award-info":[{"award-number":["12J05932"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Following small\u2010diameter vascular grafting, blood vessels fail to retain excellent antithrombotic function and therefore require application of antithrombogenic drugs. We have previously reported early attachment of endothelial cells to the luminal surface of high hydrostatic pressure (HHP)\u2010decellularized arteries after transplantation. In addition, the graft retained antithrombotic function by endothelialization and remained open for several weeks. To fabricate tube grafts of optimal size and shape for small\u2010diameter vascular grafting, we evaluated decellularized porcine aorta sheets as a suitable antithrombogenic material. Porcine aortic sheets were decellularized using detergent\u2010based or HHP methods. The HHP\u2010, but not detergent\u2010based\u2010, decellularized aortic sheets were verified to be acellular, and the mechanical properties of the native aortic sheet remained intact. To fabricate vascular grafts, the decellularized aortic sheets were rolled into tubes and secured using fibrin glue bonding. After implantation into a rat carotid artery model, the tubular grafts withstood normal blood pressure, mechanical beating, and pulsatile flow. After 3 weeks, the tubular grafts remained patent and recipient cell infiltration and cell attachment were observed on the luminal surface. These results indicate that HHP\u2010decellularized aortic sheets may be useful as an antithrombogenic material for tubular vascular grafts. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1293\u20131298, 2017.<\/jats:p>","DOI":"10.1002\/jbm.a.36017","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T08:27:13Z","timestamp":1485592033000},"page":"1293-1298","source":"Crossref","is-referenced-by-count":45,"title":["Evaluation of small\u2010diameter vascular grafts reconstructed from decellularized aorta sheets"],"prefix":"10.1002","volume":"105","author":[{"given":"Jun","family":"Negishi","sequence":"first","affiliation":[{"name":"Faculty of Textile Science and Technology Shinshu University Tokida 3\u201015\u20101 Ueda Nagano 386\u20108567 Japan"},{"name":"Department of Material\u2010Based Medical Engineering Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University 2\u20103\u201010, Kanda\u2010Surugadai Chiyoda\u2010ku Tokyo 101\u20100023 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Material\u2010Based Medical Engineering Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University 2\u20103\u201010, Kanda\u2010Surugadai Chiyoda\u2010ku Tokyo 101\u20100023 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitatsu","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Division of Acellular Tissue and Regenerative Medical Materials Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University 2\u20103\u201010 Kanda\u2010Surugadai Chiyoda\u2010ku Tokyo 101\u20100062 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Acellular Tissue and Regenerative Medical Materials Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University 2\u20103\u201010 Kanda\u2010Surugadai Chiyoda\u2010ku Tokyo 101\u20100062 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Material\u2010Based Medical Engineering Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University 2\u20103\u201010, Kanda\u2010Surugadai Chiyoda\u2010ku Tokyo 101\u20100023 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Kishida","sequence":"additional","affiliation":[{"name":"Department of Material\u2010Based Medical Engineering Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University 2\u20103\u201010, Kanda\u2010Surugadai Chiyoda\u2010ku Tokyo 101\u20100023 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Funamoto","sequence":"additional","affiliation":[{"name":"Division of Acellular Tissue and Regenerative Medical Materials Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University 2\u20103\u201010 Kanda\u2010Surugadai Chiyoda\u2010ku Tokyo 101\u20100062 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2003.12.016"},{"key":"e_1_2_6_3_1","first-page":"1561","article-title":"The use of ultrasonication to aid recellularization of acellular natural tissue scaffolds for use in anterior cruciate ligament reconstruction. 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