{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:44Z","timestamp":1786977944013,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006315","name":"Reumafonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Current treatment methods to repair meniscal tears do not bring fully satisfactory results. Tissue adhesives are considered promising alternatives, since they are easy to apply and cause minimal tissue trauma. The first aim of this study was to analyze the adhesive properties of and tissue response to two recently developed biodegradable block copolymeric three\u2010armed\u2010 and hyper\u2010branched tissue adhesives. The second aim was to investigate if tissue surface modification with collagenase improves the attachment of the adhesives and increases the healing potential of the tissue. Cylindrical explants were harvested from bovine menisci. The central core of the explants was removed and glued back into the defect, with or without incubation in collagenase solution prior to gluing, using one of the novel glues, Dermabond\u00ae or fibrin glue. The repair constructs were cultured\n                    <jats:italic>in vitro<\/jats:italic>\n                    for 1 and 28 days. Adhesion tests and histology were performed to analyze the effects of the glue in combination with the additional treatment. The adhesive strength of the novel glues was 40\u201050 kPa, which was significantly higher than that of fibrin glue (15 kPa). Cells were present in direct contact with the glues, and the tissue remained vital during the whole culture period. Increased cellularity around the tear in the collagenase treated explants was observed after 1 day. The two newly developed tissue adhesives are attractive materials to be used for repair of meniscal tears. The beneficial influence of collagenase treatment in treating meniscal tears with glues still needs to be confirmed in more clinical relevant studies. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1405\u20131411, 2017.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.36024","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T17:59:53Z","timestamp":1486058393000},"page":"1405-1411","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of novel biodegradable three\u2010armed\u2010 and hyper\u2010branched tissue adhesives in a meniscus explant model"],"prefix":"10.1002","volume":"105","author":[{"given":"A. I.","family":"Bochy\u0144ska","sequence":"first","affiliation":[{"name":"Orthopedic Research Laboratory, Department of Orthopedics Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center Nijmegen the Netherlands"},{"name":"Department of Biomaterials Science and Technology MIRA Institute, University of Twente Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hannink","sequence":"additional","affiliation":[{"name":"Orthopedic Research Laboratory, Department of Orthopedics Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Verhoeven","sequence":"additional","affiliation":[{"name":"Orthopedic Research Laboratory, Department of Orthopedics Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"Grijpma","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science and Technology MIRA Institute, University of Twente Enschede the Netherlands"},{"name":"Department of Biomedical Engineering University of Groningen, University Medical Centre Groningen, W.J. Kolff Institute Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Buma","sequence":"additional","affiliation":[{"name":"Orthopedic Research Laboratory, Department of Orthopedics Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2008.12.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(87)80004-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.10.067"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(09)70005-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513495641"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e31802ff806"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2000.4819"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658050-00003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/528359"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508314411"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(99)70035-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2003.50109"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465980260013301"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.01.016"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2012.0578"},{"key":"e_1_2_6_17_1","volume-title":"Wound Closure Biomaterials and Devices","author":"Chih\u2010Chang Chu HPG","year":"1997"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04020.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/088532829300700402"},{"key":"e_1_2_6_20_1","first-page":"30256","article-title":"Development of biodegradable hyper\u2010branched tissue adhesives for the repair of meniscus tears","volume":"12","author":"Bochynska AI","year":"2015","journal-title":"Acta Biomater"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/masy.201300101"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.03.003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546506296416"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22839"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.32604\/mcb.2006.003.197","article-title":"The effects of pro\u2010inflammatory cytokines on functional repair of the meniscus","volume":"3","author":"McNulty AL","year":"2006","journal-title":"MCB Mol Cellul Biomech"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.06.005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546506290667"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-009-0875-0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/036354659502300106"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/036354659101900614"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.36024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.36024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:08:33Z","timestamp":1694711313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.36024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,24]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/jbm.a.36024"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.36024","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,24]]}}}